Source:http://linkedlifedata.com/resource/pubmed/id/21254091
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
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| pubmed:dateCreated |
2011-1-21
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| pubmed:abstractText |
We sought to determine whether electrical stimulation (ES) with subthreshold, continuous, low-frequency impulses is a viable clinical method for improving functional recovery after facial nerve crush injury. In 10 rabbits, bilateral crush injuries were made on the facial nerve by compression for 30 s with mosquito forceps, causing complete facial paralysis. Subthreshold continuous direct current ES with 20-Hz square-wave pulses was applied to the proximal stump on one side for 4 weeks. Vibrissae movement returned significantly earlier on the ES side, with a less variable recovery time. Electrophysiologically, the stimulated side had a significantly shorter latency, longer duration, and faster conduction velocity. Light and transmission electron microscopy revealed that the electrical stimulation also markedly decreased Wallerian degeneration. The average numbers of fluorescent, double-labeled nerve cells were significantly different between the ES and non-ES sides. This study shows that subthreshold, continuous, low-frequency ES immediately after a crush injury of the facial nerve results in earlier recovery of facial function and shorter overall recovery time.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Benzofurans,
http://linkedlifedata.com/resource/pubmed/chemical/Dextrans,
http://linkedlifedata.com/resource/pubmed/chemical/Fluoro-Ruby,
http://linkedlifedata.com/resource/pubmed/chemical/Rhodamines,
http://linkedlifedata.com/resource/pubmed/chemical/true blue
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| pubmed:status |
MEDLINE
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| pubmed:month |
Feb
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| pubmed:issn |
1097-4598
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| pubmed:author | |
| pubmed:copyrightInfo |
Copyright © 2011 Wiley Periodicals, Inc.
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| pubmed:issnType |
Electronic
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| pubmed:volume |
43
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
251-8
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| pubmed:meshHeading |
pubmed-meshheading:21254091-Action Potentials,
pubmed-meshheading:21254091-Animals,
pubmed-meshheading:21254091-Benzofurans,
pubmed-meshheading:21254091-Biophysics,
pubmed-meshheading:21254091-Dextrans,
pubmed-meshheading:21254091-Disease Models, Animal,
pubmed-meshheading:21254091-Electric Stimulation Therapy,
pubmed-meshheading:21254091-Electrophysiology,
pubmed-meshheading:21254091-Facial Nerve,
pubmed-meshheading:21254091-Facial Nerve Injuries,
pubmed-meshheading:21254091-Functional Laterality,
pubmed-meshheading:21254091-Male,
pubmed-meshheading:21254091-Microscopy, Electron, Transmission,
pubmed-meshheading:21254091-Movement,
pubmed-meshheading:21254091-Muscle, Skeletal,
pubmed-meshheading:21254091-Neural Conduction,
pubmed-meshheading:21254091-Rabbits,
pubmed-meshheading:21254091-Recovery of Function,
pubmed-meshheading:21254091-Rhodamines,
pubmed-meshheading:21254091-Statistics, Nonparametric,
pubmed-meshheading:21254091-Vibrissae
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| pubmed:year |
2011
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| pubmed:articleTitle |
Subthreshold continuous electrical stimulation facilitates functional recovery of facial nerve after crush injury in rabbit.
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| pubmed:affiliation |
Department of Otorhinolaryngology, Yonsei University College of Medicine, Seoul 120-752, Korea.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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