Linked Life Data

21252111

Source:http://linkedlifedata.com/resource/pubmed/id/21252111

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
Pt 2
pubmed:dateCreated
2011-1-31
pubmed:abstractText
Behavioural variant frontotemporal dementia is characterized by a change in comportment. It is associated with considerable functional decline over the course of the illness albeit with sometimes dramatic variability among patients. It is unknown whether any baseline features, or combination of features, could predict rate of functional decline in behavioural variant frontotemporal dementia. The aim of this study was to investigate the effects of different baseline clinical, neuropsychological, neuropsychiatric, genetic and anatomic predictors on the rate of functional decline as measured by the Clinical Dementia Rating Sum of Boxes scale. We identified 86 subjects with behavioural variant frontotemporal dementia that had multiple serial Clinical Dementia Rating Sum of Boxes assessments (mean 4, range 2-18). Atlas-based parcellation was used to generate volumes for specific regions of interest at baseline. Volumes were utilized to classify subjects into different anatomical subtypes using the advanced statistical technique of cluster analysis and were assessed as predictor variables. Composite scores were generated for the neuropsychological domains of executive, language, memory and visuospatial function. Behaviours from the brief questionnaire form of the Neuropsychiatric Inventory were assessed. Linear mixed-effects regression modelling was used to determine which baseline features predict rate of future functional decline. Rates of functional decline differed across the anatomical subtypes of behavioural variant frontotemporal dementia, with faster rates observed in the frontal dominant and frontotemporal subtypes. In addition, subjects with poorer performance on neuropsychological tests of executive, language and visuospatial function, less disinhibition, agitation/aggression and night-time behaviours at presentation, and smaller medial, lateral and orbital frontal lobe volumes showed faster rates of decline. In many instances, the effect of the predictor variables observed across all subjects was also preserved within anatomical subtypes. Furthermore, some of the predictor variables improved our prediction of rate of functional decline after anatomical subtype was taken into account. In particular, age at onset was a highly significant predictor but only after adjusting for subtype. We also found that although some predictor variables, for example gender, Mini-Mental State Examination score, and apathy/indifference, did not affect the rate of functional decline; these variables were associated with the actual Clinical Dementia Rating Sum of Boxes score estimated for any given time-point. These findings suggest that in behavioural variant frontotemporal dementia, rate of functional decline is driven by the combination of anatomical pattern of atrophy, age at onset, and neuropsychiatric characteristics of the subject at baseline.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
1460-2156
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
134
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
432-48
pubmed:meshHeading
pubmed-meshheading:21252111-Adult, pubmed-meshheading:21252111-Age of Onset, pubmed-meshheading:21252111-Aged, pubmed-meshheading:21252111-Aged, 80 and over, pubmed-meshheading:21252111-Apolipoprotein E4, pubmed-meshheading:21252111-Atrophy, pubmed-meshheading:21252111-Disease Progression, pubmed-meshheading:21252111-Female, pubmed-meshheading:21252111-Frontal Lobe, pubmed-meshheading:21252111-Frontotemporal Dementia, pubmed-meshheading:21252111-Humans, pubmed-meshheading:21252111-Intercellular Signaling Peptides and Proteins, pubmed-meshheading:21252111-Male, pubmed-meshheading:21252111-Middle Aged, pubmed-meshheading:21252111-Mutation, pubmed-meshheading:21252111-Neuropsychological Tests, pubmed-meshheading:21252111-Psychiatric Status Rating Scales, pubmed-meshheading:21252111-tau Proteins
pubmed:year
2011
pubmed:articleTitle
Predicting functional decline in behavioural variant frontotemporal dementia.
pubmed:affiliation
Department of Neurology (Behavioural Neurology), Mayo Clinic, Rochester, Minnesota 55905, USA. josephs.keith@mayo.edu
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural