Source:http://linkedlifedata.com/resource/pubmed/id/21251821
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
2011-2-7
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| pubmed:abstractText |
The synthesis and inhibitory potencies of a novel series of ?-amino alcohols, based on the hit-compound 3-[3'-(4''-cyclopent-2'''-en-1'''-ylphenoxy)-2'-hydroxypropyl]-5,5 dimethylimidazolidine-2,4-dione as specific inhibitors of mycobacterial N-acetyltransferase (NAT) enzymes are reported. Effects of synthesised compounds on growth of Mycobacterium tuberculosis have been determined.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Feb
|
| pubmed:issn |
1464-3405
|
| pubmed:author | |
| pubmed:copyrightInfo |
Copyright © 2010 Elsevier Ltd. All rights reserved.
|
| pubmed:issnType |
Electronic
|
| pubmed:day |
15
|
| pubmed:volume |
21
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1185-90
|
| pubmed:meshHeading |
pubmed-meshheading:21251821-Amino Alcohols,
pubmed-meshheading:21251821-Antitubercular Agents,
pubmed-meshheading:21251821-Arylamine N-Acetyltransferase,
pubmed-meshheading:21251821-Binding Sites,
pubmed-meshheading:21251821-Catalytic Domain,
pubmed-meshheading:21251821-Computer Simulation,
pubmed-meshheading:21251821-Mycobacterium,
pubmed-meshheading:21251821-Structure-Activity Relationship
|
| pubmed:year |
2011
|
| pubmed:articleTitle |
Analysis of ?-amino alcohols as inhibitors of the potential anti-tubercular target N-acetyltransferase.
|
| pubmed:affiliation |
Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, UK.
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| pubmed:publicationType |
Journal Article
|