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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2011-5-12
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pubmed:abstractText |
2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone (RH1) is a bioreductive agent that is activated by the two-electron reductase NAD(P)H quinone oxidoreductase 1 (NQO1). Although the cytotoxic efficacy of RH1 against tumours has been studied extensively, the molecular mechanisms underlying this anti-cancer activity have not yet been fully elucidated.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/2,5-diaziridinyl-3-(hydroxymethyl)-6...,
http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Apoptosis Inducing Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Aziridines,
http://linkedlifedata.com/resource/pubmed/chemical/BAX protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Benzoquinones,
http://linkedlifedata.com/resource/pubmed/chemical/Caspases,
http://linkedlifedata.com/resource/pubmed/chemical/Endodeoxyribonucleases,
http://linkedlifedata.com/resource/pubmed/chemical/JNK Mitogen-Activated Protein...,
http://linkedlifedata.com/resource/pubmed/chemical/NAD(P)H Dehydrogenase (Quinone),
http://linkedlifedata.com/resource/pubmed/chemical/NQO1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/bcl-2-Associated X Protein,
http://linkedlifedata.com/resource/pubmed/chemical/endonuclease G
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1476-5381
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pubmed:author |
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pubmed:copyrightInfo |
© 2011 The Authors. British Journal of Pharmacology © 2011 The British Pharmacological Society.
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pubmed:issnType |
Electronic
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pubmed:volume |
163
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
567-85
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pubmed:meshHeading |
pubmed-meshheading:21250978-Antineoplastic Agents,
pubmed-meshheading:21250978-Apoptosis,
pubmed-meshheading:21250978-Apoptosis Inducing Factor,
pubmed-meshheading:21250978-Aziridines,
pubmed-meshheading:21250978-Benzoquinones,
pubmed-meshheading:21250978-Caspases,
pubmed-meshheading:21250978-Cell Line, Tumor,
pubmed-meshheading:21250978-Endodeoxyribonucleases,
pubmed-meshheading:21250978-Enzyme Activation,
pubmed-meshheading:21250978-Humans,
pubmed-meshheading:21250978-JNK Mitogen-Activated Protein Kinases,
pubmed-meshheading:21250978-Membrane Potential, Mitochondrial,
pubmed-meshheading:21250978-Mitochondria,
pubmed-meshheading:21250978-NAD(P)H Dehydrogenase (Quinone),
pubmed-meshheading:21250978-Protein Transport,
pubmed-meshheading:21250978-bcl-2-Associated X Protein
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pubmed:year |
2011
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pubmed:articleTitle |
The anti-tumour compound, RH1, causes mitochondria-mediated apoptosis by activating c-Jun N-terminal kinase.
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pubmed:affiliation |
Department of Microbiology, Center for Advanced Medical Education by BK21 Project, College of Medicine, Inha University, Incheon, Korea.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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