pubmed:abstractText |
In vitro cell culture experiments with primary cells have reported that cell proliferation is retarded in the presence of ambient compared to physiological O? levels. Cancer is primarily a disease of aberrant cell proliferation, therefore, studying cancer cells grown under ambient O? may be undesirable. To understand better the impact of O? on the propagation of cancer cells in vitro, we compared the growth potential of a panel of ovarian cancer cell lines under ambient (21%) or physiological (3%) O?.
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