| pubmed-article:21248261 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21248261 | lifeskim:mentions | umls-concept:C0032854 | lld:lifeskim |
| pubmed-article:21248261 | lifeskim:mentions | umls-concept:C1273518 | lld:lifeskim |
| pubmed-article:21248261 | lifeskim:mentions | umls-concept:C0032595 | lld:lifeskim |
| pubmed-article:21248261 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:21248261 | lifeskim:mentions | umls-concept:C1420816 | lld:lifeskim |
| pubmed-article:21248261 | lifeskim:mentions | umls-concept:C1561558 | lld:lifeskim |
| pubmed-article:21248261 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:21248261 | pubmed:dateCreated | 2011-2-3 | lld:pubmed |
| pubmed-article:21248261 | pubmed:abstractText | Capsular polysaccharides of encapsulated bacteria are weakly immunogenic T cell-independent type 2 (TI-2) Ags. Recent findings suggest that BAFF system molecules have a critical role in the development of Ab responses against TI-2 Ags. In this study, we investigated the effect of bacterial polysaccharides on B cell responses to BAFF and a proliferation-inducing ligand (APRIL). We determined that B cells exposed to meningococcal type C polysaccharide (MCPS) or group B Streptococcus serotype V (GBS-V) were unresponsive to BAFF- and APRIL-induced Ig secretion. Moreover, MCPS and GBS-V strongly downregulated transmembrane activator and calcium-modulator and cyclophilin ligand interactor, the BAFF and APRIL receptor that is responsible for Ab development against TI-2 Ags. Interestingly, (4-hydroxy-3-nitrophenyl)acetyl-Ficoll (NP-Ficoll), a prototype TI-2 Ag, did not manifest a suppressive effect on B cells. Paradoxically, whereas GBS-V and MCPS inhibited IFN-?-induced BAFF production from dendritic cells, NP-Ficoll strongly increased BAFF secretion. TLR 9 agonist CpG deoxyoligonucleotide (ODN) was able to reverse the MCPS-mediated transmembrane activator and calcium-modulator and cyclophilin ligand interactor suppression but could not rescue the Ig secretion in BAFF- or APRIL-stimulated B cells. In support of these in vitro observations, it was observed that CpG ODN could help augment the Ab response against NP in mice immunized with a CpG ODN-containing NP-Ficoll vaccine but exhibited only marginal adjuvant activity for MCPS vaccine. Collectively, these results suggest a mechanism for the weak immunogenicity of bacterial polysaccharides and explain the previously observed differences between bacterial polysaccharide and NP-Ficoll immunogenicity. | lld:pubmed |
| pubmed-article:21248261 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21248261 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21248261 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:21248261 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21248261 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21248261 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21248261 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21248261 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21248261 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21248261 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21248261 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21248261 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21248261 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21248261 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:21248261 | pubmed:issn | 1550-6606 | lld:pubmed |
| pubmed-article:21248261 | pubmed:author | pubmed-author:AkkoyunluMust... | lld:pubmed |
| pubmed-article:21248261 | pubmed:author | pubmed-author:BlakeMilan... | lld:pubmed |
| pubmed-article:21248261 | pubmed:author | pubmed-author:KanswalSunita... | lld:pubmed |
| pubmed-article:21248261 | pubmed:author | pubmed-author:AllmanWindyW | lld:pubmed |
| pubmed-article:21248261 | pubmed:author | pubmed-author:KatsenelsonNo... | lld:pubmed |
| pubmed-article:21248261 | pubmed:author | pubmed-author:UsluKadriyeK | lld:pubmed |
| pubmed-article:21248261 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21248261 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:21248261 | pubmed:volume | 186 | lld:pubmed |
| pubmed-article:21248261 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21248261 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21248261 | pubmed:pagination | 2430-43 | lld:pubmed |
| pubmed-article:21248261 | pubmed:meshHeading | pubmed-meshheading:21248261... | lld:pubmed |
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| pubmed-article:21248261 | pubmed:meshHeading | pubmed-meshheading:21248261... | lld:pubmed |
| pubmed-article:21248261 | pubmed:meshHeading | pubmed-meshheading:21248261... | lld:pubmed |
| pubmed-article:21248261 | pubmed:meshHeading | pubmed-meshheading:21248261... | lld:pubmed |
| pubmed-article:21248261 | pubmed:meshHeading | pubmed-meshheading:21248261... | lld:pubmed |
| pubmed-article:21248261 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:21248261 | pubmed:articleTitle | Suppressive effect of bacterial polysaccharides on BAFF system is responsible for their poor immunogenicity. | lld:pubmed |
| pubmed-article:21248261 | pubmed:affiliation | Laboratory of Bacterial Polysaccharides, Division of Bacterial Parasitic and Allergenic Products, Center for Biologics Evaluation and Research, US Food and Drug Administration, Bethesda, MD 20852, USA. | lld:pubmed |
| pubmed-article:21248261 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:21248261 | pubmed:publicationType | Comparative Study | lld:pubmed |
| entrez-gene:24099 | entrezgene:pubmed | pubmed-article:21248261 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:21248261 | lld:entrezgene |
