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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1991-2-4
|
| pubmed:abstractText |
Platelet transfusions from RhD-positive (D-positive) donors are often given to RhD-negative (D-negative) cancer patients. The low observed rate of alloimmunization has been attributed to disease and therapy-related immunosuppression. We have studied the occurrence of alloimmunization in 16 D-negative patients who did not have detectable anti-D prior to autologous bone marrow transplantation for malignant disease. All received D-positive platelets, but no other D-positive blood product. Three patients (19%) developed anti-D at 13, 24 and 83 days, respectively, after first receiving D-positive platelets, and after a total dose of 53, 65 and 119 D-positive platelet unit equivalents, respectively. Two of them also developed anti-C. The 13 patients in whom anti-D was not detected were also heavily transfused with D-positive platelets (mean +/- SD = 136 +/- 82 platelet unit equivalents). In 6 of them, the last recorded antibody screen was less than 3 months after the first D-positive platelets, and may not exclude a primary immune response. Thus, despite profound immunosuppression associated with autologous marrow transplantation, alloimmune responses to D-positive red cells in platelet concentrates can occur in some D-negative recipients.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0042-9007
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
59
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
185-9
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:2124754-Adolescent,
pubmed-meshheading:2124754-Adult,
pubmed-meshheading:2124754-Blood Transfusion,
pubmed-meshheading:2124754-Bone Marrow Transplantation,
pubmed-meshheading:2124754-Female,
pubmed-meshheading:2124754-Humans,
pubmed-meshheading:2124754-Isoantibodies,
pubmed-meshheading:2124754-Male,
pubmed-meshheading:2124754-Middle Aged,
pubmed-meshheading:2124754-Platelet Transfusion,
pubmed-meshheading:2124754-Rh Isoimmunization,
pubmed-meshheading:2124754-Rh-Hr Blood-Group System,
pubmed-meshheading:2124754-Transplantation, Autologous
|
| pubmed:year |
1990
|
| pubmed:articleTitle |
Alloimmunization to RhD by platelet transfusions in autologous bone marrow transplant recipients.
|
| pubmed:affiliation |
Department of Medicine, Rush-Presbyterian-St. Luke's Medical Center, Chicago, Ill.
|
| pubmed:publicationType |
Journal Article
|