Linked Life Data

21246611

Source:http://linkedlifedata.com/resource/pubmed/id/21246611

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
2011-5-13
pubmed:abstractText
Despite advances in surgical technique, rotator cuff repairs are plagued by a high rate of failure. This failure rate is in part due to poor tendon-to-bone healing; rather than regeneration of a fibrocartilaginous attachment, the repair is filled with disorganized fibrovascular (scar) tissue. Transforming growth factor beta 3 (TGF-?3) has been implicated in fetal development and scarless fetal healing and, thus, exogenous addition of TGF-?3 may enhance tendon-to-bone healing. We hypothesized that: TGF-?3 could be released in a controlled manner using a heparin/fibrin-based delivery system (HBDS); and delivery of TGF-?3 at the healing tendon-to-bone insertion would lead to improvements in biomechanical properties compared to untreated controls. After demonstrating that the release kinetics of TGF-?3 could be controlled using a HBDS in vitro, matrices were incorporated at the repaired supraspinatus tendon-to-bone insertions of rats. Animals were sacrificed at 14-56 days. Repaired insertions were assessed using histology (for inflammation, vascularity, and cell proliferation) and biomechanics (for structural and mechanical properties). TGF-?3 treatment in vivo accelerated the healing process, with increases in inflammation, cellularity, vascularity, and cell proliferation at the early timepoints. Moreover, sustained delivery of TGF-?3 to the healing tendon-to-bone insertion led to significant improvements in structural properties at 28 days and in material properties at 56 days compared to controls. We concluded that TGF-?3 delivered at a sustained rate using a HBDS enhanced tendon-to-bone healing in a rat model.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
1554-527X
pubmed:author
pubmed:copyrightInfo
Copyright © 2011 Orthopaedic Research Society.
pubmed:issnType
Electronic
pubmed:volume
29
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1099-105
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
Sustained delivery of transforming growth factor beta three enhances tendon-to-bone healing in a rat model.
pubmed:affiliation
Department of Orthopaedic Surgery, Washington University, 660 South Euclid, Campus Box 8233, St. Louis, Missouri 63110, USA.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't