Linked Life Data

21246080

Source:http://linkedlifedata.com/resource/pubmed/id/21246080

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2011-1-19
pubmed:abstractText
We studied the effect of ?-opioid receptor ligands on anxious and depressive behavior of rats. Intragastric administration of loperamide and methylnaloxone reduced animal anxiety evaluated by an increase in the number of entries into and time spent in open arms of the elevated plus-maze. ?-Opioid receptor agonist loperamide had the most pronounced anxiolytic effect. Analysis of animal behavior in the forced swimming test showed that administration of ?-opioid receptor antagonist methylnaloxone reduced the latency of the first submersion, increased the total time of submersion episodes, and shortened the time of active swimming, which attested to depressive properties of this agent. Loperamide had little effect on behavior of rats in the forced swimming test. Thus, ?-opioid receptor agonist loperamide has the antianxiety properties and produced no sedative effect. Therefore, this agent holds much promise as an anxiolytic drug.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
1573-8221
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
149
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
273-5
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Peripheral administration of loperamide and methylnaloxone decreases the degree of anxiety in rats.
pubmed:affiliation
P. K. Anokhin Institute of Normal Physiology, Russian Academy of Medical Sciences, Moscow, Russia. ssudakov@mail.ru
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't