Source:http://linkedlifedata.com/resource/pubmed/id/21245371
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
2011-3-1
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| pubmed:abstractText |
The limits of chromatographic speed and mechanical frontend capabilities have been reached for many high-volume liquid chromatography-tandem mass spectrometry (LC-MS/MS) tests, curtailing the maximal achievable sample throughput. To overcome these boundaries, we developed and validated a derivatization-based sample-multiplex LC-MS/MS assay for detection of 25-hydroxyvitamins D2 and D3 [25(OH)D2 and 25(OH)D3], which increased sample throughput 5-fold.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Mar
|
| pubmed:issn |
1530-8561
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| pubmed:author | |
| pubmed:issnType |
Electronic
|
| pubmed:volume |
57
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
431-40
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| pubmed:meshHeading |
pubmed-meshheading:21245371-25-Hydroxyvitamin D 2,
pubmed-meshheading:21245371-Automation,
pubmed-meshheading:21245371-Calcifediol,
pubmed-meshheading:21245371-Calibration,
pubmed-meshheading:21245371-Chromatography, Liquid,
pubmed-meshheading:21245371-Humans,
pubmed-meshheading:21245371-Molecular Structure,
pubmed-meshheading:21245371-Reference Standards,
pubmed-meshheading:21245371-Reproducibility of Results,
pubmed-meshheading:21245371-Sensitivity and Specificity,
pubmed-meshheading:21245371-Tandem Mass Spectrometry
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| pubmed:year |
2011
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| pubmed:articleTitle |
Increasing liquid chromatography-tandem mass spectrometry throughput by mass tagging: a sample-multiplexed high-throughput assay for 25-hydroxyvitamin D2 and D3.
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| pubmed:affiliation |
Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA.
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| pubmed:publicationType |
Journal Article
|