Source:http://linkedlifedata.com/resource/pubmed/id/21244850
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
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pubmed:dateCreated |
2011-2-14
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pubmed:abstractText |
To investigate the abnormal function of T and B lymphocytes involved in collagen-induced arthritis in DBA/1 mice and the regulation role of TACI-Ig on T and B lymphocytes, collagen-induced arthritis models were established in DBA/1 mice. Mice were divided randomly into eight groups, including normal, collagen-induced arthritis model, TACI-Ig (0.350, 1.105, 3.333, 10, and 30 mg/kg) and IgG-Fc (10mg/kg) treated groups. The effect of TACI-Ig on collagen-induced arthritis was evaluated by arthritis scores, joints and spleens histopathology, paws radiology, and indices of thymus and spleen. T and B lymphocyte proliferations were assayed by [(3)H]-TdR method. B lymphocyte stimulator and prostaglandin E(2) in serum were assayed by enzyme linked immunosorbent assay. The subsets of T and B lymphocytes were assayed by flow cytometry. Results showed that the onset of paw-swelling was on day 31 after immunization. The peak of inflammation appeared on day 42 and then declined after day 63. Compared with normal mice, collagen-induced arthritis mice have increased arthritis scores, spleen and thymus indices, radiograph scores of joints, and pathology scores of joints and spleens. TACI-Ig could ameliorate these changes and reduce the increased serum level of B lymphocyte stimulator and prostaglandin E(2). Further studies showed that TACI-Ig inhibited T and B lymphocyte proliferation response, and inhibited differentiation and activity of T and B lymphocytes in collagen-induced arthritis mice. In conclusion, TACI-Ig has a good therapeutic action on collagen-induced arthritis mice, which might be related to the regulation of TACI-Ig on inflammation mediators and abnormal function of T and B lymphocytes.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/B-Cell Activating Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Dinoprostone,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Fusion Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/TACI receptor-IgG Fc fragment...
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1879-0712
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pubmed:author | |
pubmed:copyrightInfo |
Copyright © 2010 Elsevier B.V. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:day |
11
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pubmed:volume |
654
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
304-14
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pubmed:meshHeading |
pubmed-meshheading:21244850-Animals,
pubmed-meshheading:21244850-Arthritis, Experimental,
pubmed-meshheading:21244850-Autoimmunity,
pubmed-meshheading:21244850-B-Cell Activating Factor,
pubmed-meshheading:21244850-B-Lymphocyte Subsets,
pubmed-meshheading:21244850-B-Lymphocytes,
pubmed-meshheading:21244850-Cell Proliferation,
pubmed-meshheading:21244850-Dinoprostone,
pubmed-meshheading:21244850-Joints,
pubmed-meshheading:21244850-Male,
pubmed-meshheading:21244850-Mice,
pubmed-meshheading:21244850-Recombinant Fusion Proteins,
pubmed-meshheading:21244850-Spleen,
pubmed-meshheading:21244850-T-Lymphocyte Subsets,
pubmed-meshheading:21244850-T-Lymphocytes,
pubmed-meshheading:21244850-Thymus Gland
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pubmed:year |
2011
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pubmed:articleTitle |
Therapeutic effects of TACI-Ig on collagen-induced arthritis by regulating T and B lymphocytes function in DBA/1 mice.
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pubmed:affiliation |
Institute of Clinical Pharmacology, Anhui Medical University, Key Laboratory of Anti-inflammatory and Immunopharmacology of Education Ministry of China, 230032 Hefei, PR China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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