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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2011-4-18
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pubmed:abstractText |
Overexpression of inhibitors of apoptosis proteins (IAP) contributes to therapeutic resistance. Second mitochondria-derived activator of caspase (Smac) promotes caspase activation by binding to IAPs upon release from the mitochondria. IAP antagonists, also called SMAC mimetics, are promising anticancer agents modeled after this mechanism. We investigated the role and mechanisms of Smac- and Smac mimetic-mediated chemosensitization in head and neck squamous cell carcinoma (HNSCC) cells.
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pubmed:grant |
http://linkedlifedata.com/resource/pubmed/grant/CA106348,
http://linkedlifedata.com/resource/pubmed/grant/CA121105,
http://linkedlifedata.com/resource/pubmed/grant/CA129829,
http://linkedlifedata.com/resource/pubmed/grant/R01 CA106348-04,
http://linkedlifedata.com/resource/pubmed/grant/R01 CA106348-05,
http://linkedlifedata.com/resource/pubmed/grant/R01 CA106348-06A2,
http://linkedlifedata.com/resource/pubmed/grant/R01 CA121105-03,
http://linkedlifedata.com/resource/pubmed/grant/R01 CA121105-04,
http://linkedlifedata.com/resource/pubmed/grant/R01 CA121105-05,
http://linkedlifedata.com/resource/pubmed/grant/R01 CA129829-01A1,
http://linkedlifedata.com/resource/pubmed/grant/R01 CA129829-02,
http://linkedlifedata.com/resource/pubmed/grant/R01 CA129829-03
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1078-0432
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pubmed:author |
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pubmed:copyrightInfo |
©2011 AACR.
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
17
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2361-72
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pubmed:meshHeading |
pubmed-meshheading:21242120-Animals,
pubmed-meshheading:21242120-Antimetabolites, Antineoplastic,
pubmed-meshheading:21242120-Apoptosis,
pubmed-meshheading:21242120-Biomimetic Materials,
pubmed-meshheading:21242120-Blotting, Western,
pubmed-meshheading:21242120-Caspase 3,
pubmed-meshheading:21242120-Cell Line, Tumor,
pubmed-meshheading:21242120-Cytochromes c,
pubmed-meshheading:21242120-Deoxycytidine,
pubmed-meshheading:21242120-Drug Synergism,
pubmed-meshheading:21242120-Enzyme Activation,
pubmed-meshheading:21242120-Female,
pubmed-meshheading:21242120-Head and Neck Neoplasms,
pubmed-meshheading:21242120-Humans,
pubmed-meshheading:21242120-Intracellular Signaling Peptides and Proteins,
pubmed-meshheading:21242120-Mice,
pubmed-meshheading:21242120-Mice, Nude,
pubmed-meshheading:21242120-Mitochondria,
pubmed-meshheading:21242120-Mitochondrial Proteins,
pubmed-meshheading:21242120-RNA Interference,
pubmed-meshheading:21242120-Signal Transduction,
pubmed-meshheading:21242120-Xenograft Model Antitumor Assays
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pubmed:year |
2011
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pubmed:articleTitle |
Smac modulates chemosensitivity in head and neck cancer cells through the mitochondrial apoptotic pathway.
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pubmed:affiliation |
University of Pittsburgh Cancer Institute, Hillman Cancer Center, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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