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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2011-1-18
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pubmed:abstractText |
Intravenous paracetamol (N-acetyl-paraminophenol, acetaminophen) is a widely used nonopioid analgesic which has become popular in the treatment of pain in many patient groups, including the elderly. Although intravenous paracetamol has been studied widely in clinical analgesia studies, there is little information on its pharmacokinetics in the elderly. We designed this study to determine the pharmacokinetics of intravenous paracetamol in very old patients and to compare them with that of younger patients. We also considered the effect of adenosine triphosphate-binding cassette G2 protein (ABCG2) genotype and renal function on paracetamol pharmacokinetics in these patients.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0312-5963
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
50
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
121-9
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pubmed:meshHeading |
pubmed-meshheading:21241071-ATP-Binding Cassette Transporters,
pubmed-meshheading:21241071-Acetaminophen,
pubmed-meshheading:21241071-Adult,
pubmed-meshheading:21241071-Aged,
pubmed-meshheading:21241071-Aged, 80 and over,
pubmed-meshheading:21241071-Aging,
pubmed-meshheading:21241071-Analgesia,
pubmed-meshheading:21241071-Analgesics, Non-Narcotic,
pubmed-meshheading:21241071-Area Under Curve,
pubmed-meshheading:21241071-Female,
pubmed-meshheading:21241071-Genotype,
pubmed-meshheading:21241071-Glomerular Filtration Rate,
pubmed-meshheading:21241071-Half-Life,
pubmed-meshheading:21241071-Humans,
pubmed-meshheading:21241071-Infusions, Intravenous,
pubmed-meshheading:21241071-Male,
pubmed-meshheading:21241071-Middle Aged,
pubmed-meshheading:21241071-Neoplasm Proteins,
pubmed-meshheading:21241071-Polymorphism, Single Nucleotide,
pubmed-meshheading:21241071-Sex Characteristics,
pubmed-meshheading:21241071-Young Adult
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pubmed:year |
2011
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pubmed:articleTitle |
Pharmacokinetics of intravenous paracetamol in elderly patients.
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pubmed:affiliation |
Department of Anaesthesiology, Intensive Care, Emergency Care and Pain Medicine, University of Turku and Turku University Hospital, Turku, Finland. antti.liukas@tyks.fi
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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