Linked Life Data

21240762

Source:http://linkedlifedata.com/resource/pubmed/id/21240762

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2011-1-17
pubmed:abstractText
We report the fingerprint development of a traditional Chinese medicine Radix Angelicae Dahuricae root and the correlation of the fingerprint peaks with its in vivo pharmacological effects. The high-performance liquid chromatography (HPLC) methods with the computer aided similarity evaluation were validated and used in serial pharmacological studies in mice. The major constituents of R. Angelicae Dahuricae were successfully separated by the HPLC methods, and the effects of sedation and analgesia were mainly related to the chromatographic peaks of group II. The anti-inflammatory, anti-heat stroke and anti-endotoxemic effects were mainly related to the peaks in group III. These results indicated a correlation between the HPLC fingerprints in groups and the pharmacological effects of R. Angelicae Dahuricae. This simple and accurate method can be used for the identification of the active components of R. Angelicae Dahuricae and for the quality control of its pharmaceutical preparations.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
1478-6427
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
25
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
53-61
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
Relationship between HPLC fingerprints and in vivo pharmacological effects of a traditional Chinese medicine: Radix Angelicae Dahuricae.
pubmed:affiliation
College of Pharmacy, Jinan University, Guangzhou 510632, P.R. China.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't