|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
4
|
|
pubmed:dateCreated |
2011-4-4
|
|
pubmed:abstractText |
Two F2 functional polymorphisms, rs1799963 (G20210A) and rs3136516 (A19911G), are known to be associated with elevated levels/activity of prothrombin (encoded by F2) and risk of thrombosis. Since patients with systemic lupus erythematosus (SLE) have high risk of thrombosis and accelerated atherosclerosis and also high prevalence of anti-prothrombin antibodies, we hypothesized that these two F2 polymorphisms could affect risk of SLE.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Apr
|
|
pubmed:issn |
0315-162X
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
38
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
652-7
|
|
pubmed:dateRevised |
2011-9-26
|
|
pubmed:meshHeading |
pubmed-meshheading:21239755-African Americans,
pubmed-meshheading:21239755-Alleles,
pubmed-meshheading:21239755-Atherosclerosis,
pubmed-meshheading:21239755-European Continental Ancestry Group,
pubmed-meshheading:21239755-Female,
pubmed-meshheading:21239755-Genetic Predisposition to Disease,
pubmed-meshheading:21239755-Humans,
pubmed-meshheading:21239755-Lupus Erythematosus, Systemic,
pubmed-meshheading:21239755-Polymorphism, Single Nucleotide,
pubmed-meshheading:21239755-Prothrombin,
pubmed-meshheading:21239755-Risk Factors,
pubmed-meshheading:21239755-Thrombosis
|
|
pubmed:year |
2011
|
|
pubmed:articleTitle |
Functional polymorphisms of the coagulation factor II gene (F2) and susceptibility to systemic lupus erythematosus.
|
|
pubmed:affiliation |
Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA. kamboh@pitt.edu
|
|
pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
|
