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rdf:type |
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lifeskim:mentions |
umls-concept:C0017262,
umls-concept:C0021760,
umls-concept:C0024432,
umls-concept:C0085295,
umls-concept:C0185117,
umls-concept:C0439640,
umls-concept:C0851827,
umls-concept:C1519667,
umls-concept:C1701901,
umls-concept:C2349975,
umls-concept:C2911684
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pubmed:issue |
4
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pubmed:dateCreated |
2011-2-3
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pubmed:abstractText |
Dendritic cell-specific ICAM-3-grabbing nonintegrin (DC-SIGN; CD209) is a human pathogen-attachment C-type lectin with no obvious murine ortholog and for which ligation leads to enhanced anti-inflammatory cytokine release and altered proinflammatory cytokine production. Although induced by IL-4 in monocytes and considered as a DC marker, DC-SIGN expression on human APCs under homeostatic conditions is so far unexplained. We report in this study that M-CSF enhances DC-SIGN expression on in vitro derived anti-inflammatory macrophages and that M-CSF mediates the induction of DC-SIGN by fibroblast- and tumor cell-conditioned media. The M-CSF-inducible DC-SIGN expression along monocyte-to-macrophage differentiation is dependent on JNK and STAT3 activation, potentiated by STAT3-activating cytokines (IL-6, IL-10), and abrogated by the M1-polarizing cytokine GM-CSF. In pathological settings, DC-SIGN expression is detected in tumor tissues and on ex vivo-isolated CD14(+) CD163(+) IL-10-producing tumor-associated macrophages. Importantly, DC-SIGN Abs reduced the release of IL-10 from macrophages exposed to Lewis(x)-expressing SKBR3 tumor cells. These results indicate that DC-SIGN is expressed on both wound-healing (IL-4-dependent) and regulatory (M-CSF-dependent) alternative (M2) macrophages and that DC-SIGN expression on tumor-associated macrophages might help tumor progression by contributing to the maintenance of an immunosuppressive environment.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Cell Adhesion Molecules,
http://linkedlifedata.com/resource/pubmed/chemical/Culture Media, Conditioned,
http://linkedlifedata.com/resource/pubmed/chemical/DC-specific ICAM-3 grabbing...,
http://linkedlifedata.com/resource/pubmed/chemical/IL10 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/IL6 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Inflammation Mediators,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-10,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-6,
http://linkedlifedata.com/resource/pubmed/chemical/Lectins, C-Type,
http://linkedlifedata.com/resource/pubmed/chemical/Macrophage Colony-Stimulating Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Neoplasm Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cell Surface
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1550-6606
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
15
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pubmed:volume |
186
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2192-200
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pubmed:meshHeading |
pubmed-meshheading:21239715-Adenocarcinoma,
pubmed-meshheading:21239715-Breast Neoplasms,
pubmed-meshheading:21239715-Cell Adhesion Molecules,
pubmed-meshheading:21239715-Cell Differentiation,
pubmed-meshheading:21239715-Cell Polarity,
pubmed-meshheading:21239715-Cells, Cultured,
pubmed-meshheading:21239715-Culture Media, Conditioned,
pubmed-meshheading:21239715-Dendritic Cells,
pubmed-meshheading:21239715-Disease Progression,
pubmed-meshheading:21239715-Gene Expression Regulation,
pubmed-meshheading:21239715-Humans,
pubmed-meshheading:21239715-Immunocompromised Host,
pubmed-meshheading:21239715-Inflammation Mediators,
pubmed-meshheading:21239715-Interleukin-10,
pubmed-meshheading:21239715-Interleukin-6,
pubmed-meshheading:21239715-Lectins, C-Type,
pubmed-meshheading:21239715-Macrophage Colony-Stimulating Factor,
pubmed-meshheading:21239715-Macrophages,
pubmed-meshheading:21239715-Melanoma, Experimental,
pubmed-meshheading:21239715-Neoplasm Proteins,
pubmed-meshheading:21239715-Receptors, Cell Surface,
pubmed-meshheading:21239715-Tumor Cells, Cultured
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pubmed:year |
2011
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pubmed:articleTitle |
Dendritic cell-specific ICAM-3-grabbing nonintegrin expression on M2-polarized and tumor-associated macrophages is macrophage-CSF dependent and enhanced by tumor-derived IL-6 and IL-10.
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pubmed:affiliation |
Centro de Investigaciones Biológicas, Consejo Superior de Investigaciones Científicas, Madrid, Spain. ads@cib.csic.es
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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