Source:http://linkedlifedata.com/resource/pubmed/id/21239111
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
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| pubmed:dateCreated |
2011-2-14
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| pubmed:abstractText |
Spinal cord injury (SCI) commonly results in the development of neuropathic pain, which can dramatically impair the quality of life for SCI patients. SCI-induced neuropathic pain can be manifested as both tactile allodynia (a painful sensation to a non-noxious stimulus) and hyperalgesia (an enhanced sensation to a painful stimulus). The mechanisms underlying these pain states are poorly understood. Clinical studies have shown that gabapentin, a drug that binds to the voltage-gated calcium channel alpha-2-delta-1 subunit (Ca(v)?2?-1) proteins is effective in the management of SCI-induced neuropathic pain. Accordingly, we hypothesized that tactile allodynia post SCI is mediated by an upregulation of Ca(v)?2?-1 in dorsal spinal cord. To test this hypothesis, we examined whether SCI-induced dysregulation of spinal Ca(v)?2?-1 plays a contributory role in below-level allodynia development in a rat spinal T9 contusion injury model. We found that Ca(v)?2?-1 expression levels were significantly increased in L4-6 dorsal, but not ventral, spinal cord of SCI rats that correlated with tactile allodynia development in the hind paw plantar surface. Furthermore, both intrathecal gabapentin treatment and blocking SCI-induced Ca(v)?2?-1 protein upregulation by intrathecal Ca(v)?2?-1 antisense oligodeoxynucleotides could reverse tactile allodynia in SCI rats. These findings support that SCI-induced Ca(v)?2?-1 upregulation in spinal dorsal horn is a key component in mediating below-level neuropathic pain states, and selectively targeting this pathway may provide effective pain relief for SCI patients. Spinal cord contusion injury caused increased calcium channel Ca(v)?2?-1 subunit expression in dorsal spinal cord that contributes to neuropathic pain states.
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| pubmed:grant | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Amines,
http://linkedlifedata.com/resource/pubmed/chemical/Analgesics,
http://linkedlifedata.com/resource/pubmed/chemical/Cacna2d1 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium Channels,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclohexanecarboxylic Acids,
http://linkedlifedata.com/resource/pubmed/chemical/Oligodeoxyribonucleotides, Antisense,
http://linkedlifedata.com/resource/pubmed/chemical/gabapentin,
http://linkedlifedata.com/resource/pubmed/chemical/gamma-Aminobutyric Acid
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| pubmed:status |
MEDLINE
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| pubmed:month |
Mar
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| pubmed:issn |
1872-6623
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| pubmed:author | |
| pubmed:copyrightInfo |
Copyright © 2010 International Association for the Study of Pain. Published by Elsevier B.V. All rights reserved.
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| pubmed:issnType |
Electronic
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| pubmed:volume |
152
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
649-55
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| pubmed:dateRevised |
2011-9-26
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| pubmed:meshHeading |
pubmed-meshheading:21239111-Amines,
pubmed-meshheading:21239111-Analgesics,
pubmed-meshheading:21239111-Animals,
pubmed-meshheading:21239111-Calcium Channels,
pubmed-meshheading:21239111-Cyclohexanecarboxylic Acids,
pubmed-meshheading:21239111-Disease Models, Animal,
pubmed-meshheading:21239111-Dose-Response Relationship, Drug,
pubmed-meshheading:21239111-Double-Blind Method,
pubmed-meshheading:21239111-Female,
pubmed-meshheading:21239111-Hyperalgesia,
pubmed-meshheading:21239111-Motor Activity,
pubmed-meshheading:21239111-Neuralgia,
pubmed-meshheading:21239111-Oligodeoxyribonucleotides, Antisense,
pubmed-meshheading:21239111-Pain Measurement,
pubmed-meshheading:21239111-Pain Threshold,
pubmed-meshheading:21239111-Rats,
pubmed-meshheading:21239111-Rats, Sprague-Dawley,
pubmed-meshheading:21239111-Recovery of Function,
pubmed-meshheading:21239111-Spinal Cord,
pubmed-meshheading:21239111-Spinal Cord Injuries,
pubmed-meshheading:21239111-Statistics as Topic,
pubmed-meshheading:21239111-Time Factors,
pubmed-meshheading:21239111-Up-Regulation,
pubmed-meshheading:21239111-gamma-Aminobutyric Acid
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| pubmed:year |
2011
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| pubmed:articleTitle |
Calcium channel alpha-2-delta-1 protein upregulation in dorsal spinal cord mediates spinal cord injury-induced neuropathic pain states.
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| pubmed:affiliation |
Department of Pharmacology, University of California Irvine, School of Medicine, Irvine, CA 92697, USA.
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| pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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