Linked Life Data

21238541

Source:http://linkedlifedata.com/resource/pubmed/id/21238541

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2011-2-21
pubmed:abstractText
This study is to examine if hydrogen-rich saline reduced amyloid-beta (A?) induced neural inflammation and oxidative stress in a rat model by attenuation of activation of JNK and NF-?B. Sprague-Dawley male rats (n=18, 280-330 g) were divided into three groups, sham operated, A?1-42 injected and A?1-42 plus hydrogen-rich saline treated animals. Hydrogen-rich saline (5 ml/kg, i.p., daily) was injected for 10 days after intraventricular injection of A?1-42. The levels of IL-1? were assessed by ELISA analysis, 8-OH-dG by immunohistochemistry in the brain slides, and JNK and NF-?B by immunohistochemistry and western blotting. After A?1-42 injection, the level of IL-1?, 8-OH-dG, JNK and NF-?B all increased in brain tissues, while hydrogen-rich saline treatment decreased the level of IL-1?, 8-OH-dG and the activation of JNK and NF-?B. In conclusion, hydrogen-rich saline prevented A?-induced neuroinflammation and oxidative stress, possibly by attenuation of activation of c-Jun NH?-terminal kinase (JNK) and nuclear factor-?B (NF-?B) in this rat model.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
1872-7972
pubmed:author
pubmed:copyrightInfo
Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.
pubmed:issnType
Electronic
pubmed:day
17
pubmed:volume
491
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
127-32
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
Hydrogen-rich saline reduces oxidative stress and inflammation by inhibit of JNK and NF-?B activation in a rat model of amyloid-beta-induced Alzheimer's disease.
pubmed:affiliation
Department of Neurology, the First Affiliated Hospital of China Medical University, Shenyang 110001, PR China.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't