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rdf:type |
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lifeskim:mentions |
umls-concept:C0007009,
umls-concept:C0014072,
umls-concept:C0026809,
umls-concept:C0205210,
umls-concept:C0205263,
umls-concept:C0205462,
umls-concept:C0220912,
umls-concept:C0220913,
umls-concept:C0533932,
umls-concept:C0567416,
umls-concept:C1006305,
umls-concept:C1708528
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pubmed:issue |
3
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|
pubmed:dateCreated |
2011-2-9
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pubmed:abstractText |
We have evaluated the effects of the carbon monoxide-releasing molecule CORM-A1 [Na(2) (BH(3) CO(2) ); ALF421] on the development of relapsing-remitting experimental allergic encephalomyelitis (EAE) in SJL mice, an established model of multiple sclerosis (MS). The data show that the prolonged prophylactic administration of CORM-A1 improves the clinical and histopathological signs of EAE, as shown by a reduced cumulative score, shorter duration and a lower cumulative incidence of the disease as well as milder inflammatory infiltrations of the spinal cords. This study suggests that the use of CORM-A1 might represent a novel therapeutic strategy for the treatment of multiple sclerosis.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1365-2249
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pubmed:author |
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pubmed:copyrightInfo |
© 2011 The Authors. Clinical and Experimental Immunology © 2011 British Society for Immunology.
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pubmed:issnType |
Electronic
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pubmed:volume |
163
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
368-74
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pubmed:dateRevised |
2011-8-26
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pubmed:meshHeading |
pubmed-meshheading:21235533-Animals,
pubmed-meshheading:21235533-Anti-Inflammatory Agents, Non-Steroidal,
pubmed-meshheading:21235533-Body Weight,
pubmed-meshheading:21235533-Boranes,
pubmed-meshheading:21235533-Carbon Monoxide,
pubmed-meshheading:21235533-Carbonates,
pubmed-meshheading:21235533-Dexamethasone,
pubmed-meshheading:21235533-Encephalomyelitis, Autoimmune, Experimental,
pubmed-meshheading:21235533-Female,
pubmed-meshheading:21235533-Mice,
pubmed-meshheading:21235533-Myelin Proteolipid Protein,
pubmed-meshheading:21235533-Neutrophils,
pubmed-meshheading:21235533-Peptide Fragments,
pubmed-meshheading:21235533-Spinal Cord
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pubmed:year |
2011
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pubmed:articleTitle |
Prevention of clinical and histological signs of proteolipid protein (PLP)-induced experimental allergic encephalomyelitis (EAE) in mice by the water-soluble carbon monoxide-releasing molecule (CORM)-A1.
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pubmed:affiliation |
Department of Biomedical Sciences, School of Medicine, University of Catania, Italy.
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pubmed:publicationType |
Journal Article
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