Source:http://linkedlifedata.com/resource/pubmed/id/21235518
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
2011-1-17
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pubmed:abstractText |
Previously, we reported that vitamin K(3), which consists of a quinone component, inhibits the activity of human DNA polymerase ? (pol ?). In this study, we investigated the inhibitory effects of 4 quinone derivatives (1,4-benzoquinone (BQ), 1,4-naphthoquinone (NQ), 9,10-anthraquinone (AQ) and 5,12-naphthacenequinone (NCQ)) on the activity of mammalian pols. BQ and NQ potently inhibited the activity of all the pol species: pols ?, ?, ?, ?, ? and ?, and NQ was a stronger pol inhibitor than BQ. Because we previously found a positive relationship between pol l inhibition and anti-inflammatory action, we examined whether these quinone derivatives could inhibit inflammatory responses. BQ and NQ caused a marked reduction in 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced acute inflammation in mouse ear, although AQ and NCQ did not. In a cell culture system using mouse macrophages, NQ displayed the strongest suppression in the production of tumor necrosis factor (TNF)-? induced by lipopolysaccharide (LPS) among the quinone derivatives tested. Moreover, NQ was found to inhibit the action of nuclear factor (NF)-?. In an in vivo mouse model of LPS-evoked acute inflammation, intraperitoneal injection of BQ and NQ to mice led to suppression of TNF-? production in serum. These anti-inflammatory responses of NQ were more potent than those of BQ. In conclusion, this study has identified several quinone derivatives, such as NQ, that are promising anti-inflammatory candidates.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/1,4-naphthoquinone,
http://linkedlifedata.com/resource/pubmed/chemical/Anthraquinones,
http://linkedlifedata.com/resource/pubmed/chemical/Anti-Inflammatory Agents...,
http://linkedlifedata.com/resource/pubmed/chemical/Antifibrinolytic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Directed DNA Polymerase,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Naphthoquinones,
http://linkedlifedata.com/resource/pubmed/chemical/Vitamin K 3
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1875-6638
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pubmed:author | |
pubmed:issnType |
Electronic
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pubmed:volume |
7
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
37-44
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pubmed:meshHeading |
pubmed-meshheading:21235518-Animals,
pubmed-meshheading:21235518-Anthraquinones,
pubmed-meshheading:21235518-Anti-Inflammatory Agents, Non-Steroidal,
pubmed-meshheading:21235518-Antifibrinolytic Agents,
pubmed-meshheading:21235518-Cattle,
pubmed-meshheading:21235518-Cell Line,
pubmed-meshheading:21235518-DNA-Directed DNA Polymerase,
pubmed-meshheading:21235518-Enzyme Inhibitors,
pubmed-meshheading:21235518-Female,
pubmed-meshheading:21235518-Genes, pol,
pubmed-meshheading:21235518-Humans,
pubmed-meshheading:21235518-Inflammation,
pubmed-meshheading:21235518-Macrophages,
pubmed-meshheading:21235518-Mice,
pubmed-meshheading:21235518-Mice, Inbred C57BL,
pubmed-meshheading:21235518-Naphthoquinones,
pubmed-meshheading:21235518-Rats,
pubmed-meshheading:21235518-Vitamin K 3
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pubmed:year |
2011
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pubmed:articleTitle |
Effects of quinone derivatives, such as 1,4-naphthoquinone, on DNA polymerase inhibition and anti-inflammatory action.
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pubmed:affiliation |
Division of Gastroenterology, Department of Internal Medicine, Graduate School of Medicine, Kobe University, Chuo-ku, Kobe, Hyogo 650-0017, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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