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pubmed:abstractText |
There is no treatment for fibrotic disease. TGF? is known to promote fibrogenesis in vivo and in vitro, however, development of anti-fibrotic strategies targeting the TGF? axis is problematic owing to the pleitropic nature of TGF? action. Two recent papers (Kavian et al. 2010; Nyhan et al. 2010) suggest that the jagged/Notch pathway may selectively mediate fibrogenic properties of TGF? and thus may represent a novel therapeutic approach to fibrosis for scleroderma and kidney fibrosis; these papers are the subject of this commentary.
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