Linked Life Data

21233410

Source:http://linkedlifedata.com/resource/pubmed/id/21233410

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2011-6-1
pubmed:abstractText
The biology of cells of the mononuclear phagocyte system has been studied extensively in the mouse. Studies of the pig as an experimental model have commonly been consigned to specialist animal science journals. In this review, we consider some of the many ways in which the innate immune systems of humans differ from those of mice, the ways that pigs may address the shortcomings of mice as models for the study of macrophage differentiation and activation in vitro, and the biology of sepsis and other pathologies in the living animal. With the completion of the genome sequence and the characterization of many key regulators and markers, the pig has emerged as a tractable model of human innate immunity and disease that should address the limited, predictive value of rodents in preclinical studies.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
1938-3673
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
89
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
855-71
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
The mononuclear phagocyte system of the pig as a model for understanding human innate immunity and disease.
pubmed:affiliation
The Roslin Institute and Royal (Dick) School of Veterinary Medicine, University of Edinburgh, Roslin BioCentre, Scotland, United Kingdom.
pubmed:publicationType
Journal Article, Review