| pubmed-article:21233255 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21233255 | lifeskim:mentions | umls-concept:C0021853 | lld:lifeskim |
| pubmed-article:21233255 | lifeskim:mentions | umls-concept:C0020964 | lld:lifeskim |
| pubmed-article:21233255 | lifeskim:mentions | umls-concept:C1424880 | lld:lifeskim |
| pubmed-article:21233255 | lifeskim:mentions | umls-concept:C1704259 | lld:lifeskim |
| pubmed-article:21233255 | lifeskim:mentions | umls-concept:C1705987 | lld:lifeskim |
| pubmed-article:21233255 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:21233255 | pubmed:dateCreated | 2011-2-1 | lld:pubmed |
| pubmed-article:21233255 | pubmed:abstractText | Mechanisms regulating intestinal T-cell accumulation during inflammation have considerable therapeutic value. In this study, LPS increased Staphylococcus aureus enterotoxin A-specific T cells in the gut through induction of IL-12 family members. Mice deficient in IL-12 (p35(-/-)) favored T(h)17 differentiation in lamina propria, whereas mice lacking both IL-12 and IL-23 (p40(-/-)) produced significantly fewer T(h)17 cells. However, serum analysis revealed that IL-27p28 was much higher and sustained following LPS injection than other IL-12 family cytokines. Strikingly, WSX-1 (IL-27R?) deficiency resulted in log-fold increases in lamina propria T(h)17 cells without affecting T(h)1 numbers. These results may be explained by increased expression of ?4?7 on WSX-1-deficient T cells after immunization. WSX-1-deficient regulatory T cells (Tregs) were also perturbed, producing more IL-17 and less IL-10 than wild-type Tregs. Thus, IL-27 blockade may provide a new pathway to improve mucosal vaccination. | lld:pubmed |
| pubmed-article:21233255 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21233255 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21233255 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21233255 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21233255 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21233255 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:21233255 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21233255 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21233255 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21233255 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21233255 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21233255 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21233255 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21233255 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:21233255 | pubmed:issn | 1460-2377 | lld:pubmed |
| pubmed-article:21233255 | pubmed:author | pubmed-author:VellaAnthony... | lld:pubmed |
| pubmed-article:21233255 | pubmed:author | pubmed-author:McAleerJeremy... | lld:pubmed |
| pubmed-article:21233255 | pubmed:author | pubmed-author:SarisChristia... | lld:pubmed |
| pubmed-article:21233255 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21233255 | pubmed:volume | 23 | lld:pubmed |
| pubmed-article:21233255 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21233255 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21233255 | pubmed:pagination | 129-37 | lld:pubmed |
| pubmed-article:21233255 | pubmed:meshHeading | pubmed-meshheading:21233255... | lld:pubmed |
| pubmed-article:21233255 | pubmed:meshHeading | pubmed-meshheading:21233255... | lld:pubmed |
| pubmed-article:21233255 | pubmed:meshHeading | pubmed-meshheading:21233255... | lld:pubmed |
| pubmed-article:21233255 | pubmed:meshHeading | pubmed-meshheading:21233255... | lld:pubmed |
| pubmed-article:21233255 | pubmed:meshHeading | pubmed-meshheading:21233255... | lld:pubmed |
| pubmed-article:21233255 | pubmed:meshHeading | pubmed-meshheading:21233255... | lld:pubmed |
| pubmed-article:21233255 | pubmed:meshHeading | pubmed-meshheading:21233255... | lld:pubmed |
| pubmed-article:21233255 | pubmed:meshHeading | pubmed-meshheading:21233255... | lld:pubmed |
| pubmed-article:21233255 | pubmed:meshHeading | pubmed-meshheading:21233255... | lld:pubmed |
| pubmed-article:21233255 | pubmed:meshHeading | pubmed-meshheading:21233255... | lld:pubmed |
| pubmed-article:21233255 | pubmed:meshHeading | pubmed-meshheading:21233255... | lld:pubmed |
| pubmed-article:21233255 | pubmed:meshHeading | pubmed-meshheading:21233255... | lld:pubmed |
| pubmed-article:21233255 | pubmed:meshHeading | pubmed-meshheading:21233255... | lld:pubmed |
| pubmed-article:21233255 | pubmed:meshHeading | pubmed-meshheading:21233255... | lld:pubmed |
| pubmed-article:21233255 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:21233255 | pubmed:articleTitle | The WSX-1 pathway restrains intestinal T-cell immunity. | lld:pubmed |
| pubmed-article:21233255 | pubmed:affiliation | Department of Immunology, University of Connecticut Health Center, Farmington, CT 06030, USA. | lld:pubmed |
| pubmed-article:21233255 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:21233255 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| entrez-gene:13874 | entrezgene:pubmed | pubmed-article:21233255 | lld:entrezgene |
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| entrez-gene:50931 | entrezgene:pubmed | pubmed-article:21233255 | lld:entrezgene |
