| pubmed-article:2122980 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2122980 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:2122980 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:2122980 | lifeskim:mentions | umls-concept:C1623430 | lld:lifeskim |
| pubmed-article:2122980 | lifeskim:mentions | umls-concept:C1706384 | lld:lifeskim |
| pubmed-article:2122980 | lifeskim:mentions | umls-concept:C0023470 | lld:lifeskim |
| pubmed-article:2122980 | lifeskim:mentions | umls-concept:C0010711 | lld:lifeskim |
| pubmed-article:2122980 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:2122980 | lifeskim:mentions | umls-concept:C1158770 | lld:lifeskim |
| pubmed-article:2122980 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:2122980 | pubmed:dateCreated | 1990-12-28 | lld:pubmed |
| pubmed-article:2122980 | pubmed:abstractText | Previous studies have demonstrated that 1-beta-D-arabinofuranosylcytosine (ara-C) induces terminal differentiation of human myeloid leukemia cells. Other studies have shown that the c-jun protooncogene is expressed during phorbol ester-induced myeloid differentiation. This work examines the effects of ara-C on c-jun gene expression in human KG-1 myeloid leukemia cells. The results demonstrate that c-jun transcripts are undetectable in uninduced KG-1 cells and that ara-C induces expression of this gene in a concentration- and time-dependent manner. Ara-C treatment was also associated with increases in c-jun transcripts in U-937, THP-1, and HL-60 myeloid leukemia cells. Furthermore, transcriptional run-on analysis has demonstrated that exposure to ara-C increases the rate of c-jun gene transcription. The results also demonstrate that while inhibition of protein synthesis superinduces c-jun mRNA levels in phorbol ester-treated KG-1 cells, cycloheximide had no effect on the induction of c-jun transcripts during ara-C treatment. Moreover, the half-life of c-jun transcripts in ara-C-treated KG-1 cells was 42 min. These findings suggest that the increase in c-jun mRNA observed during ara-C treatment is regulated by a transcriptional mechanism, and that c-jun may be involved in the induction of differentiation and regulation of gene expression by ara-C. | lld:pubmed |
| pubmed-article:2122980 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2122980 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2122980 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2122980 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2122980 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2122980 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2122980 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2122980 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2122980 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2122980 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2122980 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2122980 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2122980 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2122980 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2122980 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2122980 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2122980 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2122980 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2122980 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2122980 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2122980 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2122980 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2122980 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2122980 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2122980 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2122980 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2122980 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2122980 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2122980 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2122980 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2122980 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2122980 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2122980 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2122980 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2122980 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2122980 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2122980 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2122980 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2122980 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2122980 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2122980 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2122980 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2122980 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2122980 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2122980 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:2122980 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2122980 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2122980 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2122980 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2122980 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2122980 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2122980 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2122980 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2122980 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2122980 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:2122980 | pubmed:issn | 0021-9738 | lld:pubmed |
| pubmed-article:2122980 | pubmed:author | pubmed-author:KufeD WDW | lld:pubmed |
| pubmed-article:2122980 | pubmed:author | pubmed-author:ShermanM LML | lld:pubmed |
| pubmed-article:2122980 | pubmed:author | pubmed-author:KharbandaS... | lld:pubmed |
| pubmed-article:2122980 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2122980 | pubmed:volume | 86 | lld:pubmed |
| pubmed-article:2122980 | pubmed:geneSymbol | c-jun | lld:pubmed |
| pubmed-article:2122980 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2122980 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2122980 | pubmed:pagination | 1517-23 | lld:pubmed |
| pubmed-article:2122980 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:2122980 | pubmed:meshHeading | pubmed-meshheading:2122980-... | lld:pubmed |
| pubmed-article:2122980 | pubmed:meshHeading | pubmed-meshheading:2122980-... | lld:pubmed |
| pubmed-article:2122980 | pubmed:meshHeading | pubmed-meshheading:2122980-... | lld:pubmed |
| pubmed-article:2122980 | pubmed:meshHeading | pubmed-meshheading:2122980-... | lld:pubmed |
| pubmed-article:2122980 | pubmed:meshHeading | pubmed-meshheading:2122980-... | lld:pubmed |
| pubmed-article:2122980 | pubmed:meshHeading | pubmed-meshheading:2122980-... | lld:pubmed |
| pubmed-article:2122980 | pubmed:meshHeading | pubmed-meshheading:2122980-... | lld:pubmed |
| pubmed-article:2122980 | pubmed:meshHeading | pubmed-meshheading:2122980-... | lld:pubmed |
| pubmed-article:2122980 | pubmed:meshHeading | pubmed-meshheading:2122980-... | lld:pubmed |
| pubmed-article:2122980 | pubmed:meshHeading | pubmed-meshheading:2122980-... | lld:pubmed |
| pubmed-article:2122980 | pubmed:meshHeading | pubmed-meshheading:2122980-... | lld:pubmed |
| pubmed-article:2122980 | pubmed:meshHeading | pubmed-meshheading:2122980-... | lld:pubmed |
| pubmed-article:2122980 | pubmed:meshHeading | pubmed-meshheading:2122980-... | lld:pubmed |
| pubmed-article:2122980 | pubmed:meshHeading | pubmed-meshheading:2122980-... | lld:pubmed |
| pubmed-article:2122980 | pubmed:meshHeading | pubmed-meshheading:2122980-... | lld:pubmed |
| pubmed-article:2122980 | pubmed:meshHeading | pubmed-meshheading:2122980-... | lld:pubmed |
| pubmed-article:2122980 | pubmed:meshHeading | pubmed-meshheading:2122980-... | lld:pubmed |
| pubmed-article:2122980 | pubmed:meshHeading | pubmed-meshheading:2122980-... | lld:pubmed |
| pubmed-article:2122980 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:2122980 | pubmed:articleTitle | Transcriptional regulation of c-jun gene expression by arabinofuranosylcytosine in human myeloid leukemia cells. | lld:pubmed |
| pubmed-article:2122980 | pubmed:affiliation | Laboratory of Clinical Pharmacology, Dana-Farber Cancer Institute, Boston, Massachusetts 02115. | lld:pubmed |
| pubmed-article:2122980 | pubmed:publicationType | Journal Article | lld:pubmed |
