Linked Life Data

21228503

Source:http://linkedlifedata.com/resource/pubmed/id/21228503

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2011-1-13
pubmed:abstractText
We have shown that the rate of brain protein synthesis in aged rats depended on the quality and quantity of dietary protein consumed. The purpose of this study was to determine whether the quality and quantity of dietary protein affected the phosphorylation of eukaryotic initiation factor (eIF) 4E-binding protein 1 (4E-BP1) and ribosomal protein S6 kinase (S6K1) and regulated the brain protein synthesis. Two experiments were done on three groups of 24-wk-old male rats given diets containing 20% casein, 20% gluten, or 20% gelatin (Experiment 1), and 20% casein, 5% casein or 0% casein (Experiment 2) for 10 d. The phosphorylation of S6K1 in both the cerebral cortex and cerebellum, and the phosphorylation of 4E-BP1 in the cerebral cortex declined with a decrease of quality and quantity of dietary protein. The phosphorylation of 4E-BP1 in the cerebellum did not differ among groups. The results suggest that the ingestion of a higher quality and quantity of dietary protein stimulates the phosphorylation of 4E-BP1 and S6K1 in the brain and increases the brain protein synthesis in the aged rats.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1881-7742
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
56
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
319-25
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Effect of quality and quantity of dietary protein on 4E-BP1 and S6K1 phosphorylation of brains in aged rats.
pubmed:affiliation
Laboratory of Nutritional Biochemistry, School of Food and Nutritional Sciences, COE Program in the 21st Century, The University of Shizuoka, Suruga, Japan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't