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rdf:type |
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lifeskim:mentions |
umls-concept:C0017262,
umls-concept:C0024501,
umls-concept:C0026473,
umls-concept:C0033268,
umls-concept:C0039194,
umls-concept:C0085295,
umls-concept:C0086418,
umls-concept:C0108747,
umls-concept:C0185117,
umls-concept:C0721534,
umls-concept:C0962190,
umls-concept:C1332714,
umls-concept:C1414555,
umls-concept:C2911684
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pubmed:issue |
2
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pubmed:dateCreated |
2011-2-9
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pubmed:abstractText |
Interleukin 21 exerts a variety of regulatory effects on both innate and adaptive immune cells. Although the suppressive effect of IL-21 via the induction of IL-10 in mouse model has been defined, the inhibitory effect of IL-21 in humans is not well understood. In the present study, we showed that IL-21 induced IL-10 production by human naive CD4(+) T cells. Most of the IL-10-producing CD4(+) T cells did not co-express IFN-?. IL-21 increased the expression of IL-21R on activated naïve CD4(+) T cells. Further analysis indicated that IL-21 induced phosphorylation of STAT1, STAT3 and STAT5 in activated naïve CD4(+) T cells. In addition, IL-21 maintained the expression of CD16 on monocytes via the production of IL-10 by human naïve CD4(+) T cells. Taken together, our data indicated that IL-21 had a modulating effect on monocytes at least in part by inducing IL-10 production.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD28,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD3,
http://linkedlifedata.com/resource/pubmed/chemical/Culture Media, Conditioned,
http://linkedlifedata.com/resource/pubmed/chemical/FCGR3B protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/GPI-Linked Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-DR Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/IL10 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/IL21R protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-10,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-21 Receptor alpha...,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, IgG,
http://linkedlifedata.com/resource/pubmed/chemical/STAT1 Transcription Factor,
http://linkedlifedata.com/resource/pubmed/chemical/STAT1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/STAT3 Transcription Factor,
http://linkedlifedata.com/resource/pubmed/chemical/STAT3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/STAT5 Transcription Factor,
http://linkedlifedata.com/resource/pubmed/chemical/interleukin-21
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pubmed:status |
MEDLINE
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pubmed:issn |
1090-2163
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pubmed:author |
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pubmed:copyrightInfo |
Copyright © 2011 Elsevier Inc. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:volume |
267
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
102-8
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pubmed:meshHeading |
pubmed-meshheading:21227406-Antibodies,
pubmed-meshheading:21227406-Antigens, CD28,
pubmed-meshheading:21227406-Antigens, CD3,
pubmed-meshheading:21227406-CD4-Positive T-Lymphocytes,
pubmed-meshheading:21227406-Culture Media, Conditioned,
pubmed-meshheading:21227406-Fetal Blood,
pubmed-meshheading:21227406-GPI-Linked Proteins,
pubmed-meshheading:21227406-HLA-DR Antigens,
pubmed-meshheading:21227406-Humans,
pubmed-meshheading:21227406-Interferon-gamma,
pubmed-meshheading:21227406-Interleukin-10,
pubmed-meshheading:21227406-Interleukin-21 Receptor alpha Subunit,
pubmed-meshheading:21227406-Interleukins,
pubmed-meshheading:21227406-Leukocytes, Mononuclear,
pubmed-meshheading:21227406-Lymphocyte Activation,
pubmed-meshheading:21227406-Monocytes,
pubmed-meshheading:21227406-Phosphorylation,
pubmed-meshheading:21227406-Receptors, IgG,
pubmed-meshheading:21227406-STAT1 Transcription Factor,
pubmed-meshheading:21227406-STAT3 Transcription Factor,
pubmed-meshheading:21227406-STAT5 Transcription Factor
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pubmed:year |
2011
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pubmed:articleTitle |
Interleukin-21 maintains the expression of CD16 on monocytes via the production of IL-10 by human naïve CD4+ T cells.
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pubmed:affiliation |
Department of Immunology, Zhongshan School of Medicine, Key Laboratory of Tropical Disease Control Research of Ministry of Education, Sun Yat-sen University, Guangzhou, China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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