Linked Life Data

21226884

Source:http://linkedlifedata.com/resource/pubmed/id/21226884

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2011-1-13
pubmed:abstractText
Gastrointestinal dysmotility presenting as nausea, vomiting, bloating, diarrhea, constipation or abdominal pain is seen in diabetic patients. Oxidative stress has recently been recognized as a significant player in the pathogenesis of gastrointestinal complications of diabetes. In this issue of Neurogastroenterology and Motility, a team of investigators from Emory University led by Dr. Srinivasan present new evidence on the effect of oxidative stress in the diabetic colon. They show in diabetic patients, increased oxidative stress is associated with loss of the inhibitory neuronal subpopulation of enteric neurons, and that the neuronal loss can be reversed in-vitro by anti-oxidant lipoic acid. This new information adds to the accumulating evidence on the deleterious effect of oxidative stress in the gastrointestinal tract and highlights the opportunity to develop newer therapies focused on augmenting anti-oxidant defenses in the gastrointestinal tract in diabetic patients.
pubmed:grant
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
1365-2982
pubmed:author
pubmed:copyrightInfo
© 2011 Blackwell Publishing Ltd.
pubmed:issnType
Electronic
pubmed:volume
23
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
111-4
pubmed:dateRevised
2011-9-26
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
Oxidative stress: key player in gastrointestinal complications of diabetes.
pubmed:affiliation
Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA.
pubmed:publicationType
Journal Article, Comment, Research Support, N.I.H., Extramural