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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2011-2-21
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pubmed:abstractText |
The hippocampus plays an important role in learning and memory and possibly contributes to the formation of pain-related memory and emotional responses. However, there is currently little data linking the hippocampus to neuropathic pain. It has been reported that NF-?B is an important regulatory factor in memory consolidation within the hippocampus. This study aims to examine a possible relationship between the hippocampal NF-?B expression and nerve injury-induced thermal hyperalgesia using a rat model of constriction sciatic nerve injury (CCI). Immunofluorescence and Western blot analysis were performed to detect and quantify the hippocampal NF-?B expression. Thermal hyperalgesia was examined on day 0 and postoperative days 1, 7 and 14. The nuclear portion of the p65 NF-?B expression was significantly increased on the contralateral side on days 7 and 14 as well as significantly increased on the ipsilateral side on day 14 as compared to the sham control group. Intraperitoneal administration of MK-801, an N-methyl-d-aspartate (NMDA) receptor antagonist, reduced hyperalgesia and modulated the NF-?B expression in the contralateral side of hippocampus. These results suggest an association between the hippocampal NF-?B expression and the behavioral manifestation of thermal hyperalgesia, which is likely to be mediated through activation of the NMDA receptor.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1872-6240
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pubmed:author |
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pubmed:copyrightInfo |
Copyright © 2011 Elsevier B.V. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:day |
10
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pubmed:volume |
1378
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
66-71
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pubmed:meshHeading |
pubmed-meshheading:21223950-Animals,
pubmed-meshheading:21223950-Blotting, Western,
pubmed-meshheading:21223950-Dizocilpine Maleate,
pubmed-meshheading:21223950-Excitatory Amino Acid Antagonists,
pubmed-meshheading:21223950-Fluorescent Antibody Technique,
pubmed-meshheading:21223950-Functional Laterality,
pubmed-meshheading:21223950-Hippocampus,
pubmed-meshheading:21223950-Hot Temperature,
pubmed-meshheading:21223950-Hyperalgesia,
pubmed-meshheading:21223950-Ligation,
pubmed-meshheading:21223950-Male,
pubmed-meshheading:21223950-NF-kappa B,
pubmed-meshheading:21223950-Neuralgia,
pubmed-meshheading:21223950-Rats,
pubmed-meshheading:21223950-Rats, Sprague-Dawley,
pubmed-meshheading:21223950-Receptors, N-Methyl-D-Aspartate,
pubmed-meshheading:21223950-Sciatic Nerve
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pubmed:year |
2011
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pubmed:articleTitle |
Peripheral nerve injury alters the expression of NF-?B in the rat's hippocampus.
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pubmed:affiliation |
MGH Center for Translational Pain Research, Department of Anesthesia and Critical Care, WACC 324, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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