Linked Life Data

21222457

Source:http://linkedlifedata.com/resource/pubmed/id/21222457

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2011-2-17
pubmed:databankReference
pubmed:abstractText
Antimicrobial activity and solution structures of four 13-amino acid peptides derived from the fusion domain of viral hemagglutinin proteins are presented. The results show that carboxyl-terminal amidation is a key factor to switch a viral fusion domain-derived sequence into an antimicrobial peptide. Optimization of amphiphilic balance on the amidated analogue largely improves efficacy and enlarges antimicrobial spectra of these peptides. Our work indicates that viral fusion domains have potential to be engineered into potent antimicrobial peptides.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
1520-4804
pubmed:author
pubmed:issnType
Electronic
pubmed:day
24
pubmed:volume
54
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1091-5
pubmed:meshHeading
pubmed-meshheading:21222457-Amino Acid Sequence, pubmed-meshheading:21222457-Animals, pubmed-meshheading:21222457-Anti-Infective Agents, pubmed-meshheading:21222457-Antimicrobial Cationic Peptides, pubmed-meshheading:21222457-Bacteria, pubmed-meshheading:21222457-Hemagglutinin Glycoproteins, Influenza Virus, pubmed-meshheading:21222457-Hemolysis, pubmed-meshheading:21222457-Influenza A Virus, H3N2 Subtype, pubmed-meshheading:21222457-Magnetic Resonance Spectroscopy, pubmed-meshheading:21222457-Mice, pubmed-meshheading:21222457-Microbial Sensitivity Tests, pubmed-meshheading:21222457-Models, Molecular, pubmed-meshheading:21222457-Molecular Sequence Data, pubmed-meshheading:21222457-Spectrometry, Mass, Matrix-Assisted Laser..., pubmed-meshheading:21222457-Structure-Activity Relationship, pubmed-meshheading:21222457-Viral Fusion Proteins
pubmed:year
2011
pubmed:articleTitle
Convergent evolution-guided design of antimicrobial peptides derived from influenza A virus hemagglutinin.
pubmed:affiliation
Group of Animal Innate Immunity, State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, 1 Beichen West Road, Chaoyang District, Beijing 100101, China. Zhusy@ioz.ac.cn
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't