Linked Life Data

21222184

Source:http://linkedlifedata.com/resource/pubmed/id/21222184

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2011-1-14
pubmed:abstractText
The in vivo regulation of erythropoiesis involves the integration of a range of intrinsic and cell extrinsic cues. The macrophage contained within the erythroblastic island is central to the normal differentiation and support of erythroid development. The contributions of other cell types found within the local bone marrow microenvironment are also likely to play important roles depending on the context. Such cell types include osteoblasts, osteoclasts, adipocytes, endothelial cells in addition to developing hematopoietic cells. There are data correlating changes in erythroid homeostasis, particularly in anemic states such as hemoglobinopathies, with alterations in the skeleton. The interaction and coordination of erythroid development and skeletal homeostasis, particularly in setting of erythroid demand, may represent a centrally regulated axis that is important physiologically, pharmacologically and in the pathology of anemia states.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
1865-3774
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
93
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
10-3
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
Erythropoiesis, anemia and the bone marrow microenvironment.
pubmed:affiliation
St. Vincent's Institute of Medical Research, Department of Medicine, St. Vincent's Hospital, University of Melbourne, 9 Princes St, Fitzroy, VIC 3065, Australia. cwalkley@svi.edu.au
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't