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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2011-6-24
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pubmed:abstractText |
Ovarian cancer is often diagnosed in women after menopause when the levels of the serum gonadotropins follicle-stimulating hormone (FSH) and luteinizing hormone (LH) are increased because of the depletion of growing follicles within the ovary. The ability of FSH and LH to modulate the disease has not been well studied owing to a lack of physiologically relevant models of ovarian cancer. In this study, 4-vinylcyclohexene diepoxide (VCD) was used to deplete ovarian follicles and increase the levels of circulating FSH and LH in the tgCAG-LS-TAg mouse model of ovarian cancer.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1530-0374
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
18
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
549-57
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pubmed:meshHeading |
pubmed-meshheading:21221022-Animals,
pubmed-meshheading:21221022-Cell Line, Tumor,
pubmed-meshheading:21221022-Cyclohexenes,
pubmed-meshheading:21221022-Disease Models, Animal,
pubmed-meshheading:21221022-Female,
pubmed-meshheading:21221022-Follicle Stimulating Hormone,
pubmed-meshheading:21221022-Humans,
pubmed-meshheading:21221022-Luteinizing Hormone,
pubmed-meshheading:21221022-Menopause,
pubmed-meshheading:21221022-Mice,
pubmed-meshheading:21221022-Mice, Transgenic,
pubmed-meshheading:21221022-Ovarian Follicle,
pubmed-meshheading:21221022-Ovarian Neoplasms,
pubmed-meshheading:21221022-Sertoli Cell Tumor,
pubmed-meshheading:21221022-Simian virus 40,
pubmed-meshheading:21221022-Vinyl Compounds
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pubmed:year |
2011
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pubmed:articleTitle |
Induction of a menopausal state alters the growth and histology of ovarian tumors in a mouse model of ovarian cancer.
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pubmed:affiliation |
Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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