Linked Life Data

2122023

Source:http://linkedlifedata.com/resource/pubmed/id/2122023

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1990-12-19
pubmed:abstractText
Whether tryptophan in the usual dose found in total parenteral nutrition (TPN) solutions caused a decrease in food intake was investigated in 16 adult male Fischer 344 rats. A jugular venous catheter was placed, and patency was maintained with a continuous infusion of normal saline at 3 ml/hr. After a 10-day recovery period, eight normal saline control rats were sacrificed and the remaining eight rats were given a parenteral nutrition solution (PN-50) at 3 ml/hr, providing 50% of the rat's daily energy requirement as 5% dextrose and 2% Intralipid. On day 14, study rats were further divided into two subgroups. Subgroup A received tryptophan (180 mg/day) added to the solution for 5 days. Subgroup B received the serotonin-receptor blocker, cyproheptadine 24 mg/kg/day, continuously for 5 days, and on day 16, tryptophan (0.25% = 180 mg/kg/day) was added to the solution for 3 days. Chow and water was continuously available and spontaneous food intake was measured daily. Study rats were sacrificed on day 19. Plasma amino acids and insulin and whole brain biogenic amines were compared with those in control rats using Student's t-test. With administration of PN-50, spontaneous food intake decreased to about 60% compared with the pre-PN level. The addition of tryptophan to the continuous infusion of PN-50 did not decrease spontaneous food intake further.(ABSTRACT TRUNCATED AT 250 WORDS)
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0148-6071
pubmed:author
pubmed:issnType
Print
pubmed:volume
14
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
497-500
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:articleTitle
Effect of tryptophan and cyproheptadine on food intake.
pubmed:affiliation
Department of Surgery, University Hospital, SUNY Health Science Center, Syracuse 13210.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.