Source:http://linkedlifedata.com/resource/pubmed/id/21220180
Switch to
Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
|
pubmed:dateCreated |
2011-1-25
|
pubmed:abstractText |
The synthesis of four new isoxazoline-based amino acids being analogues of previously described glutamate receptor ligands is reported and their affinity for ionotropic glutamate receptors is analyzed in comparison with that of selected model compounds. Molecular modelling investigations have been carried out to rationalize the interaction with the NMDA receptors.
|
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Feb
|
pubmed:issn |
1768-3254
|
pubmed:author | |
pubmed:copyrightInfo |
Copyright © 2010 Elsevier Masson SAS. All rights reserved.
|
pubmed:issnType |
Electronic
|
pubmed:volume |
46
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
787-93
|
pubmed:meshHeading |
pubmed-meshheading:21220180-Amino Acids,
pubmed-meshheading:21220180-Binding Sites,
pubmed-meshheading:21220180-Isoxazoles,
pubmed-meshheading:21220180-Ligands,
pubmed-meshheading:21220180-Models, Molecular,
pubmed-meshheading:21220180-Molecular Conformation,
pubmed-meshheading:21220180-Receptors, Ionotropic Glutamate,
pubmed-meshheading:21220180-Stereoisomerism,
pubmed-meshheading:21220180-Structure-Activity Relationship
|
pubmed:year |
2011
|
pubmed:articleTitle |
Synthesis of new isoxazoline-based acidic amino acids and investigation of their affinity and selectivity profile at ionotropic glutamate receptors.
|
pubmed:affiliation |
Dipartimento di Scienze Farmaceutiche Pietro Pratesi, Università degli Studi di Milano, Via Mangiagalli 25, 20133 Milano, Italy.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|