| pubmed-article:21219344 | pubmed:abstractText | The purpose of this study was to investigate the hemolymph kinetics and depuration time of oxytetracycline following intramuscular administration at doses of 2, 8 and 40?mg/kg body weight, respectively. The concentration of OTC in hemolymph was assayed using solid phase extraction and high performance liquid chromatography. The elimination half-life of the terminal part of the elimination phase (t(1/2?) ) ranged from 87.9 to 114.3?h. The total body clearance (CL(b) ) was 0.0430?L/kg/h at the lower dose, 0.0123?L/kg/h at the medium dose and 0.0013?L/kg/h at the higher dose. The apparent volume of the central compartment (V(c) ) was found to be 1.383, 0.699 and 0.143?L/kg respectively. The depuration time for each dose was 13.6, 29.6 and 57.6?days, respectively. Results from the present study suggest that the 40?mg/kg dose might have the best therapeutic efficacy following intramuscular administration. | lld:pubmed |
