Linked Life Data

21219344

Source:http://linkedlifedata.com/resource/pubmed/id/21219344

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2011-1-11
pubmed:abstractText
The purpose of this study was to investigate the hemolymph kinetics and depuration time of oxytetracycline following intramuscular administration at doses of 2, 8 and 40?mg/kg body weight, respectively. The concentration of OTC in hemolymph was assayed using solid phase extraction and high performance liquid chromatography. The elimination half-life of the terminal part of the elimination phase (t(1/2?) ) ranged from 87.9 to 114.3?h. The total body clearance (CL(b) ) was 0.0430?L/kg/h at the lower dose, 0.0123?L/kg/h at the medium dose and 0.0013?L/kg/h at the higher dose. The apparent volume of the central compartment (V(c) ) was found to be 1.383, 0.699 and 0.143?L/kg respectively. The depuration time for each dose was 13.6, 29.6 and 57.6?days, respectively. Results from the present study suggest that the 40?mg/kg dose might have the best therapeutic efficacy following intramuscular administration.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
1365-2885
pubmed:author
pubmed:copyrightInfo
© 2010 Blackwell Publishing Ltd.
pubmed:issnType
Electronic
pubmed:volume
34
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
51-7
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
Pharmacokinetics of oxytetracycline in hemolymph from the Chinese mitten crab, Eriocheir sinensis.
pubmed:affiliation
Jiangsu Key Laboratory for Biodiversity & Biotechnology and Jiangsu Key Laboratory of Aquatic Crustacean Animal Diseases, College of Life Sciences, Nanjing Normal University, Nanjing, China.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't