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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2011-2-22
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pubmed:abstractText |
Hydrophobically modified maghemite (?-Fe(2)O(3)) nanoparticles were encapsulated within the membrane of poly(trimethylene carbonate)-b-poly(l-glutamic acid) (PTMC-b-PGA) block copolymer vesicles using a nanoprecipitation process. This formation method gives simple access to highly magnetic nanoparticles (MNPs) (loaded up to 70 wt %) together with good control over the vesicles size (100-400 nm). The simultaneous loading of maghemite nanoparticles and doxorubicin was also achieved by nanoprecipitation. The deformation of the vesicle membrane under an applied magnetic field has been evidenced by small angle neutron scattering. These superparamagnetic hybrid self-assemblies display enhanced contrast properties that open potential applications for magnetic resonance imaging. They can also be guided in a magnetic field gradient. The feasibility of controlled drug release by radio frequency magnetic hyperthermia was demonstrated in the case of encapsulated doxorubicin molecules, showing the viability of the concept of magneto-chemotherapy. These magnetic polymersomes can be used as efficient multifunctional nanocarriers for combined therapy and imaging.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Biocompatible Materials,
http://linkedlifedata.com/resource/pubmed/chemical/Contrast Media,
http://linkedlifedata.com/resource/pubmed/chemical/Dioxanes,
http://linkedlifedata.com/resource/pubmed/chemical/Doxorubicin,
http://linkedlifedata.com/resource/pubmed/chemical/Drug Carriers,
http://linkedlifedata.com/resource/pubmed/chemical/Ferric Compounds,
http://linkedlifedata.com/resource/pubmed/chemical/Membranes, Artificial,
http://linkedlifedata.com/resource/pubmed/chemical/Polyglutamic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Polymers,
http://linkedlifedata.com/resource/pubmed/chemical/ferric oxide,
http://linkedlifedata.com/resource/pubmed/chemical/polytrimethylene carbonate
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1936-086X
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pubmed:author |
pubmed-author:BrûletAnnieA,
pubmed-author:BrissonAlainA,
pubmed-author:DiouOdileO,
pubmed-author:DupuisVincentV,
pubmed-author:IbarboureEmmanuelE,
pubmed-author:LecommandouxSébastienS,
pubmed-author:MirauxSylvainS,
pubmed-author:SandreOlivierO,
pubmed-author:SansonCharlesC,
pubmed-author:SoumAlainA,
pubmed-author:TanSisareuthS,
pubmed-author:ThévenotJulieJ,
pubmed-author:ThiaudièreEricE
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pubmed:issnType |
Electronic
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pubmed:day |
22
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pubmed:volume |
5
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1122-40
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pubmed:meshHeading |
pubmed-meshheading:21218795-Antineoplastic Agents,
pubmed-meshheading:21218795-Biocompatible Materials,
pubmed-meshheading:21218795-Chemical Precipitation,
pubmed-meshheading:21218795-Contrast Media,
pubmed-meshheading:21218795-Dioxanes,
pubmed-meshheading:21218795-Doxorubicin,
pubmed-meshheading:21218795-Drug Carriers,
pubmed-meshheading:21218795-Ferric Compounds,
pubmed-meshheading:21218795-Humans,
pubmed-meshheading:21218795-Hydrophobic and Hydrophilic Interactions,
pubmed-meshheading:21218795-Hyperthermia, Induced,
pubmed-meshheading:21218795-Magnetic Field Therapy,
pubmed-meshheading:21218795-Magnetic Resonance Imaging,
pubmed-meshheading:21218795-Magnetics,
pubmed-meshheading:21218795-Membranes, Artificial,
pubmed-meshheading:21218795-Motion,
pubmed-meshheading:21218795-Nanostructures,
pubmed-meshheading:21218795-Polyglutamic Acid,
pubmed-meshheading:21218795-Polymers
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pubmed:year |
2011
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pubmed:articleTitle |
Doxorubicin loaded magnetic polymersomes: theranostic nanocarriers for MR imaging and magneto-chemotherapy.
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pubmed:affiliation |
Universite? de Bordeaux/IPB, ENSCBP, 16 avenue Pey Berland, 33607 Pessac Cedex, France.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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