Source:http://linkedlifedata.com/resource/pubmed/id/21218069
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
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pubmed:dateCreated |
2011-1-10
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pubmed:abstractText |
A simple, precise, specific, and accurate reverse phase HPLC method has been developed for the determination of pregabalin in capsule dosage form. The chromatography was set on Hypersil BDS, C8, 150×4.6 mm, 5 ?m column using photodiode array detector. The mobile phase consisting of phosphate buffer pH 6.9 and acetonitrile in the ratio of 95:05 with flow rate of 1 ml/min. The method was validated according to ICH guidelines with respect to specificity, linearity, accuracy, precision and robustness. Lower limit of quantification is 0.6 mg/l. The pregabalin sample solution was found to be stable at room temperature for about 26 h.
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pubmed:commentsCorrections | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:status |
PubMed-not-MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1998-3743
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pubmed:author | |
pubmed:issnType |
Electronic
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pubmed:volume |
72
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
517-9
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pubmed:dateRevised |
2011-7-20
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pubmed:year |
2010
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pubmed:articleTitle |
Development and validation of HPLC method for the determination of pregabalin in capsules.
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pubmed:affiliation |
Dr. Rafiq Zakaria Campus, Post Graduate Studies and Research Centre, Moulana Azad College Rouza Bagh, Aurangabad-431 00, India.
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pubmed:publicationType |
Journal Article
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