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pubmed-article:21216837pubmed:abstractTextPulmonary hypertension as a frequent complication of left heart disease (PH-LHD) is characterized by lung endothelial dysfunction and vascular remodeling. Although PH-LHD contributes to morbidity and mortality in heart failure, established therapies for PH-LHD are lacking. We tested the effect of chronic sildenafil treatment in an experimental model of PH-LHD.lld:pubmed
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pubmed-article:21216837pubmed:dateRevised2011-10-27lld:pubmed
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pubmed-article:21216837pubmed:articleTitleSildenafil preserves lung endothelial function and prevents pulmonary vascular remodeling in a rat model of diastolic heart failure.lld:pubmed
pubmed-article:21216837pubmed:affiliationKeenan Research Centre at the Li Ka Shing Knowledge Institute, St Michael's Hospital, Toronto, Ontario, Canada.lld:pubmed
pubmed-article:21216837pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:21216837pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed