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rdf:type |
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lifeskim:mentions |
umls-concept:C0014257,
umls-concept:C0024109,
umls-concept:C0026336,
umls-concept:C0033085,
umls-concept:C0034693,
umls-concept:C0034721,
umls-concept:C0529793,
umls-concept:C0542341,
umls-concept:C1135196,
umls-concept:C1292733,
umls-concept:C1801960,
umls-concept:C2709248
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pubmed:issue |
2
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pubmed:dateCreated |
2011-3-16
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pubmed:abstractText |
Pulmonary hypertension as a frequent complication of left heart disease (PH-LHD) is characterized by lung endothelial dysfunction and vascular remodeling. Although PH-LHD contributes to morbidity and mortality in heart failure, established therapies for PH-LHD are lacking. We tested the effect of chronic sildenafil treatment in an experimental model of PH-LHD.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1941-3297
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
4
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
198-206
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pubmed:dateRevised |
2011-10-27
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pubmed:meshHeading |
pubmed-meshheading:21216837-Administration, Oral,
pubmed-meshheading:21216837-Animals,
pubmed-meshheading:21216837-Antihypertensive Agents,
pubmed-meshheading:21216837-Cyclic GMP,
pubmed-meshheading:21216837-Cyclic Nucleotide Phosphodiesterases, Type 5,
pubmed-meshheading:21216837-Disease Models, Animal,
pubmed-meshheading:21216837-Endothelium, Vascular,
pubmed-meshheading:21216837-Heart Failure, Diastolic,
pubmed-meshheading:21216837-Hypertension, Pulmonary,
pubmed-meshheading:21216837-Hypertrophy, Left Ventricular,
pubmed-meshheading:21216837-Hypertrophy, Right Ventricular,
pubmed-meshheading:21216837-Lung,
pubmed-meshheading:21216837-Male,
pubmed-meshheading:21216837-Nitric Oxide,
pubmed-meshheading:21216837-Phosphodiesterase 5 Inhibitors,
pubmed-meshheading:21216837-Piperazines,
pubmed-meshheading:21216837-Pulmonary Artery,
pubmed-meshheading:21216837-Purines,
pubmed-meshheading:21216837-Rats,
pubmed-meshheading:21216837-Rats, Sprague-Dawley,
pubmed-meshheading:21216837-Sulfones,
pubmed-meshheading:21216837-Time Factors,
pubmed-meshheading:21216837-Vascular Resistance,
pubmed-meshheading:21216837-Vasodilation,
pubmed-meshheading:21216837-Ventricular Function, Left,
pubmed-meshheading:21216837-Ventricular Function, Right
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pubmed:year |
2011
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pubmed:articleTitle |
Sildenafil preserves lung endothelial function and prevents pulmonary vascular remodeling in a rat model of diastolic heart failure.
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pubmed:affiliation |
Keenan Research Centre at the Li Ka Shing Knowledge Institute, St Michael's Hospital, Toronto, Ontario, Canada.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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