rdf:type |
|
lifeskim:mentions |
umls-concept:C0018591,
umls-concept:C0036341,
umls-concept:C0085295,
umls-concept:C0085762,
umls-concept:C0086860,
umls-concept:C0149561,
umls-concept:C0205419,
umls-concept:C0332281,
umls-concept:C0679109,
umls-concept:C1333254,
umls-concept:C1882417
|
pubmed:issue |
2
|
pubmed:dateCreated |
2011-6-13
|
pubmed:abstractText |
A total of 934 patients with schizophrenia and 433 controls were genotyped for the interleukin-10 (IL-10) promoter and DRD4 uVNTR polymorphisms. DRD4 long-form variants (namely, those with ?5 repeats), homozygosity for the 4-repeat allele, and the IL-10 haplotype ACA were associated with schizophrenia, respectively. No obvious interactions among the potential polymorphisms were found, which suggests that IL-10 and DRD4 confer vulnerability to schizophrenia independently.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Jul
|
pubmed:issn |
0165-1781
|
pubmed:author |
|
pubmed:copyrightInfo |
Copyright © 2010 Elsevier Ltd. All rights reserved.
|
pubmed:issnType |
Print
|
pubmed:day |
30
|
pubmed:volume |
188
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
294-6
|
pubmed:meshHeading |
pubmed-meshheading:21216474-Cohort Studies,
pubmed-meshheading:21216474-Female,
pubmed-meshheading:21216474-Genetic Predisposition to Disease,
pubmed-meshheading:21216474-Genome-Wide Association Study,
pubmed-meshheading:21216474-Genotype,
pubmed-meshheading:21216474-Humans,
pubmed-meshheading:21216474-Interleukin-10,
pubmed-meshheading:21216474-Male,
pubmed-meshheading:21216474-Minisatellite Repeats,
pubmed-meshheading:21216474-Models, Genetic,
pubmed-meshheading:21216474-Polymorphism, Genetic,
pubmed-meshheading:21216474-Promoter Regions, Genetic,
pubmed-meshheading:21216474-Receptors, Dopamine D4,
pubmed-meshheading:21216474-Schizophrenia,
pubmed-meshheading:21216474-Taiwan
|
pubmed:year |
2011
|
pubmed:articleTitle |
The interleukin 10 promoter haplotype ACA and the long-form variant of the DRD4 uVNTR polymorphism are associated with vulnerability to schizophrenia.
|
pubmed:affiliation |
Department of Psychiatry, Kaohsiung Armed Forces General Hospital, Kaohsiung, Taiwan. forwey@seed.net.tw
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|