Linked Life Data

21215724

Source:http://linkedlifedata.com/resource/pubmed/id/21215724

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2011-2-14
pubmed:abstractText
The pharmacologic characteristics of glycine receptors (GlyRs) in the lateral superior olive (LSO) of circling mice, animal model for inherited deafness, were investigated using a GlyR ?1 subunit-specific receptor blocker (cyanotriphenylborate [CTB]). There was a statistically significant age-dependent increase in the antagonistic effect of CTB in heterozygous (+/cir) mice. In postnatal (P)0-P3 heterozygous (+/cir) mice, glycine currents evoked by glycine puffs were reduced to 20.4±2.6, 37.1±3.1, and 63.9±2.5% at 0.1, 1, and 10 ?M CTB (n=13) compared to controls, while the glycine currents were reduced to 22.3±3.5, 52.9±4.1, and 78.3±3.5% at 0.1, 1, and 10 ?M CTB (n=7) in P8-P12 heterozygous (+/cir) mice. In contrast, the antagonistic effect of CTB was not strong and even less than that of younger animals in older homozygous (cir/cir) mice. In P0-P3 homozygous (cir/cir) mice, the extent of inhibition was 20.2±3.7, 37.8±4.3, and 66.8±4.2% at 0.1, 1, and 10 ?M CTB (n=6) compared to controls, while the extent of inhibition was 18.7±2.4, 28.1±3.9, and 39.1±8.2% (n=6) in P8-P12 homozygous (cir/cir) mice. The age-dependent decrease in the antagonistic effect of CTB indicates the abnormal development of the ?1 subunit-containing GlyRs in homozygous (cir/cir) mice.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
1090-2104
pubmed:author
pubmed:copyrightInfo
Copyright © 2011 Elsevier Inc. All rights reserved.
pubmed:issnType
Electronic
pubmed:day
11
pubmed:volume
405
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
157-61
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
Glycine-induced currents are insensitive to the glycine receptor ?1 subunit-specific blocker, cyanotriphenylborate, in older circling mice.
pubmed:affiliation
Department of Nanobio Medical Science, Dankook University, San 29, Anseo-dong, Cheonan-si, Chungnam 330-714, South Korea.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't