Source:http://linkedlifedata.com/resource/pubmed/id/21215285
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
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| pubmed:dateCreated |
2011-2-14
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| pubmed:abstractText |
Chlamydia trachomatis-induced fallopian tube damage leading to tubal factor infertility (TFI) is linked with TNF, IL-10, and probably IFNG gene polymorphisms. The aim of this study was to clarify the contribution of these cytokine gene polymorphisms to interindividual variation in C trachomatis-specific immune responses and the cross-regulation of secreted cytokines and single nucleotide polymorphisms (SNPs). Cytokine polymorphisms (IL-10 -1082A/G, -819T/C, and -592A/C, IFNG +874T/A, and TNF -308G/A) were genotyped by polymerase chain reaction in 139 women. C trachomatis-specific immune responses were measured using lymphocyte proliferation (LP) induced by C trachomatis E and F strains and chlamydial heat shock protein 60 antigens. Cytokine secretion was measured in culture supernatants of infected and uninfected mononuclear leukocytes. IL-10 -1082/-819/-592 and IFNG +874 SNPs were associated with the intensity of LP responses to C trachomatis antigens. These cytokines also interact with each other and a cumulative effect of IL-10 -1082 and IFNG +874 genotypes was seen in LP responses to C trachomatis antigens. Our data suggest that interleukin-10 and interferon-? regulate C trachomatis-specific immune responses in humans and that genetic variation in the expression of their coding genes explains interindividual variation in host immune responses to C trachomatis infection.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Bacterial,
http://linkedlifedata.com/resource/pubmed/chemical/Chaperonin 60,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-10,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha
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| pubmed:status |
MEDLINE
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| pubmed:month |
Mar
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| pubmed:issn |
1879-1166
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| pubmed:author | |
| pubmed:copyrightInfo |
Copyright © 2011. Published by Elsevier Inc.
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| pubmed:issnType |
Electronic
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| pubmed:volume |
72
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
278-82
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| pubmed:meshHeading |
pubmed-meshheading:21215285-Adolescent,
pubmed-meshheading:21215285-Adult,
pubmed-meshheading:21215285-Antibodies, Bacterial,
pubmed-meshheading:21215285-Chaperonin 60,
pubmed-meshheading:21215285-Chlamydia Infections,
pubmed-meshheading:21215285-Chlamydia trachomatis,
pubmed-meshheading:21215285-Fallopian Tube Diseases,
pubmed-meshheading:21215285-Female,
pubmed-meshheading:21215285-Gene Expression,
pubmed-meshheading:21215285-Genetic Variation,
pubmed-meshheading:21215285-Genotype,
pubmed-meshheading:21215285-Humans,
pubmed-meshheading:21215285-Infertility, Female,
pubmed-meshheading:21215285-Interferon-gamma,
pubmed-meshheading:21215285-Interleukin-10,
pubmed-meshheading:21215285-Leukocytes, Mononuclear,
pubmed-meshheading:21215285-Lymphocyte Count,
pubmed-meshheading:21215285-Middle Aged,
pubmed-meshheading:21215285-Polymerase Chain Reaction,
pubmed-meshheading:21215285-Polymorphism, Single Nucleotide,
pubmed-meshheading:21215285-Tumor Necrosis Factor-alpha
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| pubmed:year |
2011
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| pubmed:articleTitle |
Cytokine gene polymorphism and Chlamydia trachomatis-specific immune responses.
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| pubmed:affiliation |
National Institute for Health and Welfare, Oulu, Finland.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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