Linked Life Data

21214538

Source:http://linkedlifedata.com/resource/pubmed/id/21214538

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2011-1-10
pubmed:abstractText
Seizures in the human temporal lobe transiently impair cognition and steadily damage hippocampal circuitry, leading to progressive memory loss. Similarly, the toxic accumulation of A? peptides underlying Alzheimer's disease (AD) triggers synaptic degeneration, circuit remodeling, and abnormal synchronization within the same networks. Because neuronal hyperexcitability amplifies the synaptic release of A?, seizures create a vicious spiral that accelerates cell death and cognitive decline in the AD brain. The confluence of hyperexcitability and excitotoxicity, combined with the challenge of seizure detection in the human hippocampus, make epilepsy in these individuals extremely important to correctly diagnose and treat. Emerging clinical evidence reveals an elevated comorbidity of epilepsy in AD, particularly when linked to mutations in the APP/A? gene pathway. Experimental models in genetically engineered mice confirm and extend these findings, highlighting the presence of subclinical seizures and overlapping pathophysiologic cascades. There is an urgent need for more clinical and basic investigation to improve the early recognition of hippocampal seizures arising during the course of dementing disorders, and to validate molecular blockers of A?-induced aberrant excitability that can slow and potentially reverse the progression of cognitive decline.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
1528-1167
pubmed:author
pubmed:copyrightInfo
Wiley Periodicals, Inc. © 2011 International League Against Epilepsy.
pubmed:issnType
Electronic
pubmed:volume
52 Suppl 1
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
39-46
pubmed:dateRevised
2011-3-17
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
A perfect storm: Converging paths of epilepsy and Alzheimer's dementia intersect in the hippocampal formation.
pubmed:affiliation
Department of Neurology, Baylor College of Medicine, Houston, Texas 77030, USA. jnoebels@bcm.edu
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural