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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2011-2-17
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pubmed:abstractText |
Nicotine induces the proliferation of non-small cell lung cancer (NSCLC) cells via nicotinic acetylcholine receptors and the arrestin, ?1 (ARRB1) protein. However, whether ARRB1 translocates to the nucleus upon nicotinic acetylcholine receptor activation and how it regulates growth of human NSCLCs are not known.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1460-2105
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
16
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pubmed:volume |
103
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
317-33
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pubmed:meshHeading |
pubmed-meshheading:21212384-Apoptosis,
pubmed-meshheading:21212384-Arrestins,
pubmed-meshheading:21212384-Carcinoma, Non-Small-Cell Lung,
pubmed-meshheading:21212384-Cell Line, Tumor,
pubmed-meshheading:21212384-Cell Proliferation,
pubmed-meshheading:21212384-E2F Transcription Factors,
pubmed-meshheading:21212384-Fluorescent Antibody Technique,
pubmed-meshheading:21212384-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:21212384-Humans,
pubmed-meshheading:21212384-Immunoblotting,
pubmed-meshheading:21212384-Immunoprecipitation,
pubmed-meshheading:21212384-Lung,
pubmed-meshheading:21212384-Lung Neoplasms,
pubmed-meshheading:21212384-Microscopy, Confocal,
pubmed-meshheading:21212384-Nicotine,
pubmed-meshheading:21212384-Polymerase Chain Reaction,
pubmed-meshheading:21212384-RNA, Messenger,
pubmed-meshheading:21212384-Smoking,
pubmed-meshheading:21212384-Up-Regulation
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pubmed:year |
2011
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pubmed:articleTitle |
ARRB1-mediated regulation of E2F target genes in nicotine-induced growth of lung tumors.
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pubmed:affiliation |
Department of Oncologic Sciences, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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