Linked Life Data

21211553

Source:http://linkedlifedata.com/resource/pubmed/id/21211553

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2011-3-3
pubmed:abstractText
An immunocytochemical comparison of vGluT1 and vGluT3 in the cochlear nucleus (CN) of deafened versus normal hearing rats showed the first example of vGluT3 immunostaining in the dorsal and ventral CN and revealed temporal and spatial changes in vGluT1 localization in the CN after cochlear injury. In normal hearing rats vGluT1 immunostaining was restricted to terminals on CN neurons while vGluT3 immunolabeled the somata of the neurons. This changed in the ventral cochlear nucleus (VCN) 3 days following deafness, where vGluT1 immunostaining was no longer seen in large auditory nerve terminals but was instead found in somata of VCN neurons. In the dorsal cochlear nucleus (DCN), while vGluT1 labeling of terminals decreased, there was no labeling of neuronal somata. Therefore, loss of peripheral excitatory input results in co-localization of vGluT1 and vGluT3 in VCN neuronal somata. Postsynaptic glutamatergic neurons can use retrograde signaling to control their presynaptic inputs and these results suggest vGluTs could play a role in regulating retrograde signaling in the CN under different conditions of excitatory input. Changes in vGluT gene expression in CN neurons were found 3 weeks following deafness using qRT-PCR with significant increases in vGluT1 gene expression in both ventral and dorsal CN while vGluT3 gene expression decreased in VCN but increased in DCN.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
1873-7544
pubmed:author
pubmed:copyrightInfo
Copyright © 2011 IBRO. Published by Elsevier Ltd. All rights reserved.
pubmed:issnType
Electronic
pubmed:day
31
pubmed:volume
178
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
218-39
pubmed:meshHeading
pubmed-meshheading:21211553-Animals, pubmed-meshheading:21211553-Cell Count, pubmed-meshheading:21211553-Cell Size, pubmed-meshheading:21211553-Cochlear Nucleus, pubmed-meshheading:21211553-Evoked Potentials, Auditory, Brain Stem, pubmed-meshheading:21211553-Gene Expression, pubmed-meshheading:21211553-Hearing Loss, pubmed-meshheading:21211553-Immunohistochemistry, pubmed-meshheading:21211553-Male, pubmed-meshheading:21211553-Neuronal Plasticity, pubmed-meshheading:21211553-Neurons, pubmed-meshheading:21211553-Rats, pubmed-meshheading:21211553-Rats, Sprague-Dawley, pubmed-meshheading:21211553-Synaptic Transmission, pubmed-meshheading:21211553-Time Factors, pubmed-meshheading:21211553-Vesicular Glutamate Transport Protein 1, pubmed-meshheading:21211553-Vesicular Glutamate Transport Proteins
pubmed:year
2011
pubmed:articleTitle
Vesicular glutamate transporters: spatio-temporal plasticity following hearing loss.
pubmed:affiliation
Department of Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit, MI 48201, USA.
pubmed:publicationType
Journal Article, Research Support, N.I.H., Extramural