| pubmed-article:2121092 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2121092 | lifeskim:mentions | umls-concept:C0027575 | lld:lifeskim |
| pubmed-article:2121092 | lifeskim:mentions | umls-concept:C0080194 | lld:lifeskim |
| pubmed-article:2121092 | lifeskim:mentions | umls-concept:C0012854 | lld:lifeskim |
| pubmed-article:2121092 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:2121092 | lifeskim:mentions | umls-concept:C0042333 | lld:lifeskim |
| pubmed-article:2121092 | lifeskim:mentions | umls-concept:C0135892 | lld:lifeskim |
| pubmed-article:2121092 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:2121092 | pubmed:dateCreated | 1990-11-6 | lld:pubmed |
| pubmed-article:2121092 | pubmed:abstractText | A 2-kilobase fragment containing the penicillin-binding protein 2 gene (penA) was amplified by using the polymerase chain reaction with DNA prepared from 35 penicillin-resistant strains of Neisseria meningitidis isolated in England, Ireland, and Spain (MICs, 0.16 to 1.28 micrograms of benzylpenicillin per ml) and from 10 penicillin-susceptible strains (MICs, less than or equal to 0.04 micrograms of benzylpenicillin per ml). The penA genes were digested with HpaII or TaqYI; and the resulting fragments were end-labeled, fractionated on a polyacrylamide gel, and autoradiographed, to produce gene fingerprints. The fingerprints of the penA genes of the 10 penicillin-susceptible strains were identical. In contrast, the fingerprints of the penA genes of all but two of the penicillin-resistant strains differed markedly from those of the penicillin-susceptible strains. The altered penA genes of group B penicillin-resistant strains were very diverse, and 14 different fingerprints were found among the 15 strains that we examined. The penA genes of the 19 resistant group C strains were less diverse, and two major fingerprint patterns predominated. | lld:pubmed |
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| pubmed-article:2121092 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2121092 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2121092 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:2121092 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2121092 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:2121092 | pubmed:issn | 0066-4804 | lld:pubmed |
| pubmed-article:2121092 | pubmed:author | pubmed-author:JonesD MDM | lld:pubmed |
| pubmed-article:2121092 | pubmed:author | pubmed-author:Pérez... | lld:pubmed |
| pubmed-article:2121092 | pubmed:author | pubmed-author:SprattB GBG | lld:pubmed |
| pubmed-article:2121092 | pubmed:author | pubmed-author:ZhangQ YQY | lld:pubmed |
| pubmed-article:2121092 | pubmed:author | pubmed-author:Sáez NietoJ... | lld:pubmed |
| pubmed-article:2121092 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2121092 | pubmed:volume | 34 | lld:pubmed |
| pubmed-article:2121092 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2121092 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2121092 | pubmed:pagination | 1523-8 | lld:pubmed |
| pubmed-article:2121092 | pubmed:dateRevised | 2010-8-25 | lld:pubmed |
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| pubmed-article:2121092 | pubmed:meshHeading | pubmed-meshheading:2121092-... | lld:pubmed |
| pubmed-article:2121092 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:2121092 | pubmed:articleTitle | Genetic diversity of penicillin-binding protein 2 genes of penicillin-resistant strains of Neisseria meningitidis revealed by fingerprinting of amplified DNA. | lld:pubmed |
| pubmed-article:2121092 | pubmed:affiliation | Microbial Genetics Group, School of Biological Sciences, University of Sussex, Brighton, United Kingdom. | lld:pubmed |
| pubmed-article:2121092 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2121092 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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