Source:http://linkedlifedata.com/resource/pubmed/id/21210775
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
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| pubmed:dateCreated |
2011-1-26
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| pubmed:abstractText |
Fetomaternal alloimmune thrombocytopenia (FMAIT) is the most common cause of severe neonatal thrombocytopenia in otherwise well, term infants. First pregnancies are often severely affected. This descriptive, population-based national study was undertaken in order to inform the case for antenatal screening. Cases were identified using three sources and capture-recapture techniques used to generate a robust incidence estimate. One hundred and seventy three cases were identified between October 2006 and September 2008. An extra 20 cases were estimated from capture-recapture analysis, giving an estimated incidence of clinically detected FMAIT of 12·4 cases per 100?000 total births (95%confidence interval: 10·7, 14·3). Fifty-two cases (30%) were known at the start of pregnancy; 120 (70%) were unknown (n=115) or unrecognized (n=5). Unknown cases were more likely to experience a haemorrhagic complication (67% vs. 5%) (P<0·001) and more likely to have an intracranial haemorrhage (20% vs. 4%) (P=0·014) than known cases receiving antenatal management. In view of the incidence of severe disease identified, further assessment of the case for antenatal screening is important. There were a number of cases in which the significance of a history of FMAIT in a previous sibling was not recognized and there is a need to raise awareness of the importance of this diagnosis.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:status |
MEDLINE
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| pubmed:month |
Feb
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| pubmed:issn |
1365-2141
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| pubmed:author | |
| pubmed:copyrightInfo |
© 2011 Blackwell Publishing Ltd.
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| pubmed:issnType |
Electronic
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| pubmed:volume |
152
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
460-8
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| pubmed:meshHeading |
pubmed-meshheading:21210775-Female,
pubmed-meshheading:21210775-Gestational Age,
pubmed-meshheading:21210775-Great Britain,
pubmed-meshheading:21210775-Hemorrhage,
pubmed-meshheading:21210775-Humans,
pubmed-meshheading:21210775-Incidence,
pubmed-meshheading:21210775-Infant, Newborn,
pubmed-meshheading:21210775-Platelet Count,
pubmed-meshheading:21210775-Population Surveillance,
pubmed-meshheading:21210775-Pregnancy,
pubmed-meshheading:21210775-Pregnancy Outcome,
pubmed-meshheading:21210775-Prenatal Diagnosis,
pubmed-meshheading:21210775-Prognosis,
pubmed-meshheading:21210775-Thrombocytopenia, Neonatal Alloimmune
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| pubmed:year |
2011
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| pubmed:articleTitle |
The incidence and outcomes of fetomaternal alloimmune thrombocytopenia: a UK national study using three data sources.
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| pubmed:affiliation |
National Perinatal Epidemiology Unit, University of Oxford, Oxford NHS Blood and Transplant Nuffield Department of Clinical Laboratory Sciences, John Radcliffe Hospital, University of Oxford, Oxford, UK. Marian.knight@npeu.ox.ac.uk
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| pubmed:publicationType |
Journal Article
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