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rdf:type |
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lifeskim:mentions |
umls-concept:C0007634,
umls-concept:C0016030,
umls-concept:C0017337,
umls-concept:C0035696,
umls-concept:C0086418,
umls-concept:C0205314,
umls-concept:C0449445,
umls-concept:C0679622,
umls-concept:C1527178,
umls-concept:C1705938,
umls-concept:C1879547
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pubmed:issue |
12
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pubmed:dateCreated |
2011-1-6
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pubmed:abstractText |
Several methods have been used to induce somatic cells to re-enter the pluripotent state. Viral transduction of reprogramming genes yields higher efficiency but involves random insertions of viral sequences into the human genome. Although induced pluripotent stem (iPS) cells can be obtained with the removable PiggyBac transposon system or an episomal system, both approaches still use DNA constructs so that resulting cell lines need to be thoroughly analyzed to confirm they are free of harmful genetic modification. Thus a method to change cell fate without using DNA will be very useful in regenerative medicine.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/21209933-11071754,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21209933-11875572,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21209933-15385941,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21209933-15558047,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21209933-16210403,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21209933-16968779,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21209933-17554301,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21209933-17615585,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21209933-17635643,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21209933-18029452,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21209933-18035408,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21209933-18276851,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21209933-18393968,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21209933-18414659,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21209933-18522845,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21209933-18568017,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21209933-18754011,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21209933-18773085,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21209933-18983962,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/21209933-19505649,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/21209933-19668186,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21209933-19668188,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21209933-19668189,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21209933-19668190,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21209933-19668191,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21209933-19696146,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21209933-20188704,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21209933-20336525,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21209933-20668695,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21209933-20691899,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21209933-20888316,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21209933-2443243,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21209933-7720076,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21209933-9738504
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1932-6203
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
5
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
e14397
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pubmed:dateRevised |
2011-7-20
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pubmed:meshHeading |
pubmed-meshheading:21209933-Alkaline Phosphatase,
pubmed-meshheading:21209933-Cell Culture Techniques,
pubmed-meshheading:21209933-Cell Differentiation,
pubmed-meshheading:21209933-Cell Nucleus,
pubmed-meshheading:21209933-Cloning, Molecular,
pubmed-meshheading:21209933-Fibroblasts,
pubmed-meshheading:21209933-Genetic Techniques,
pubmed-meshheading:21209933-Humans,
pubmed-meshheading:21209933-Induced Pluripotent Stem Cells,
pubmed-meshheading:21209933-Models, Genetic,
pubmed-meshheading:21209933-Nuclear Reprogramming,
pubmed-meshheading:21209933-Polymerase Chain Reaction,
pubmed-meshheading:21209933-RNA, Messenger,
pubmed-meshheading:21209933-Regenerative Medicine,
pubmed-meshheading:21209933-Transcription, Genetic
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pubmed:year |
2010
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pubmed:articleTitle |
Activation of pluripotency genes in human fibroblast cells by a novel mRNA based approach.
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pubmed:affiliation |
Biomedical Science Department, Centre for Stem Cell Biology, University of Sheffield, Sheffield, United Kingdom.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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