Linked Life Data

21209257

Source:http://linkedlifedata.com/resource/pubmed/id/21209257

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2011-2-21
pubmed:abstractText
APOA5 is one of the strongest regulators of plasma TG concentrations; nevertheless, its mechanisms of action are poorly characterized. Genetic variability at the APOA5 locus has also been associated with increased cardiovascular disease risk; however, this predisposition could be attenuated in the context of a prudent diet as traditionally consumed in the Mediterranean countries. We have investigated the interaction between a single nucleotide polymorphism (SNP) at the APOA5 gene (-1131T > C) and dietary fat that may modulate TG-rich lipoprotein concentrations and anthropometric measures in overweight and obese participants. We recruited 1465 participants from a Spanish population (20-65 y old; BMI 25-40 kg/m(2)) attending outpatient obesity clinics. Consistent with previous reports, we found an association between the APOA5-1131T > C SNP and TG-rich lipoprotein concentrations that were higher in carriers of the minor allele than in noncarriers (P < 0.001). Moreover, we found a significant genotype-dietary fat interaction for obesity traits. Participants homozygous for the -1131T major allele had a positive association between fat intake and obesity, whereas in those carrying the APOA5-1131C minor allele, higher fat intakes were not associated with higher BMI. Likewise, we found genotype-dietary fat interactions for TG-rich lipoproteins (P < 0.001). In conclusion, we have replicated previous gene-diet interactions between APOA5 -1131T > C SNP and fat intake for obesity traits and detected a novel interaction for TG-rich lipoprotein concentrations. Our data support the hypothesis that the minor C-allele may protect those consuming a high-fat diet from obesity and elevated concentrations of TG-rich lipoproteins.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
1541-6100
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
141
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
380-5
pubmed:meshHeading
pubmed-meshheading:21209257-Adult, pubmed-meshheading:21209257-Aged, pubmed-meshheading:21209257-Apolipoproteins A, pubmed-meshheading:21209257-Body Mass Index, pubmed-meshheading:21209257-Cardiovascular Diseases, pubmed-meshheading:21209257-Dietary Fats, pubmed-meshheading:21209257-Female, pubmed-meshheading:21209257-Genetic Association Studies, pubmed-meshheading:21209257-Humans, pubmed-meshheading:21209257-Hypertriglyceridemia, pubmed-meshheading:21209257-Lipoproteins, pubmed-meshheading:21209257-Lipoproteins, VLDL, pubmed-meshheading:21209257-Male, pubmed-meshheading:21209257-Mediterranean Region, pubmed-meshheading:21209257-Middle Aged, pubmed-meshheading:21209257-Obesity, pubmed-meshheading:21209257-Overweight, pubmed-meshheading:21209257-Polymorphism, Single Nucleotide, pubmed-meshheading:21209257-Promoter Regions, Genetic, pubmed-meshheading:21209257-Risk Factors, pubmed-meshheading:21209257-Spain, pubmed-meshheading:21209257-Triglycerides, pubmed-meshheading:21209257-Young Adult
pubmed:year
2011
pubmed:articleTitle
APOA5 gene variation interacts with dietary fat intake to modulate obesity and circulating triglycerides in a Mediterranean population.
pubmed:affiliation
Department of Physiology, University of Murcia, Campus de Espinardo, s/n. 30100, Murcia, Spain.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural