Linked Life Data

21208487

Source:http://linkedlifedata.com/resource/pubmed/id/21208487

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
2011-3-25
pubmed:abstractText
Trans-fatty acids (TFA) and cis-monounsaturated fat appear to exert detrimental and beneficial effects, respectively, on glucose metabolism and insulin sensitivity. Adipose tissue and skeletal muscle are a source of signalling proteins (adipokines and myokines), some of which have been related to the control of insulin sensitivity. Here, we investigated the possible differential effects of elaidic acid (EA; trans-9-18 : 1) - the major component in industrially produced TFA - and oleic acid (OA; cis-9-18 : 1) - its cis-isomer naturally present in food - on cellular glucose uptake and the expression of selected myokines and adipokines using cell models. Differentiated C2C12 myotubes and 3T3-L1 adipocytes were pretreated with the vehicle (control cells) or fatty acids for 24 h, after which basal and insulin-stimulated 2-deoxyglucose uptake and the expression of selected signalling proteins were measured. In C2C12 myotubes, pretreatment with OA, but not with EA, led to increased insulin-stimulated 2-deoxyglucose uptake and IL-6 expression levels, while pretreatment with EA, but not with OA, led to reduced IL-15 mRNA levels and increased TNF-? expression levels. In 3T3-L1 adipocytes, exposure to OA, but not to EA, resulted in reduced resistin gene expression and increased adiponectin gene expression. The results show evidence of distinct, direct effects of OA and EA on muscle glucose uptake and the expression of target myokines and adipokines, thus suggesting novel mechanisms by which cis- and trans-monounsaturated fat may differentially affect systemic functions.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
1475-2662
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
105
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1226-34
pubmed:meshHeading
pubmed-meshheading:21208487-3T3-L1 Cells, pubmed-meshheading:21208487-Adipocytes, pubmed-meshheading:21208487-Adipokines, pubmed-meshheading:21208487-Animals, pubmed-meshheading:21208487-Antimetabolites, pubmed-meshheading:21208487-Biological Transport, pubmed-meshheading:21208487-Cell Differentiation, pubmed-meshheading:21208487-Cell Line, pubmed-meshheading:21208487-Cytokines, pubmed-meshheading:21208487-Deoxyglucose, pubmed-meshheading:21208487-Gene Expression Regulation, pubmed-meshheading:21208487-Glucose, pubmed-meshheading:21208487-Mice, pubmed-meshheading:21208487-Muscle Fibers, Skeletal, pubmed-meshheading:21208487-Oleic Acid, pubmed-meshheading:21208487-RNA, Messenger, pubmed-meshheading:21208487-Signal Transduction, pubmed-meshheading:21208487-Stereoisomerism, pubmed-meshheading:21208487-Trans Fatty Acids
pubmed:year
2011
pubmed:articleTitle
Distinct effects of oleic acid and its trans-isomer elaidic acid on the expression of myokines and adipokines in cell models.
pubmed:affiliation
Laboratory of Molecular Biology, Nutrition and Biotechnology, Universitat de les Illes Balears, CIBER de Fisiopatología de la Obesidad y Nutrición (CIBERobn), Cra. Valldemossa, Km 7.5, 07122 Palma de Mallorca, Spain.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't